Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions

The biocatalytic stereocontrolled synthesis of various acyclic anti - or syn -α-alkyl-β-amino amides through a dynamic kinetic resolution strategy is demonstrated. A series of commercially available and in-house transaminases (TAs) were employed to perform the transamination of a series of chemicall...

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Veröffentlicht in:	Catalysis science & technology 2019-07, Vol.9 (15), p.483-49
Hauptverfasser:	Mourelle-Insua, Ángela, Méndez-Sánchez, Daniel, Galman, James L, Slabu, Iustina, Turner, Nicholas J, Gotor-Fernández, Vicente, Lavandera, Iván
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides NMR Nuclear magnetic resonance Optical activity Organic chemistry Stereoselectivity Substrates Synthesis Transaminases
Online-Zugang:	Volltext
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