Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots
The reversible volume transition of redox-responsive hydrogels by near-infrared (NIR) irradiation has recently attracted significant attention as a novel therapy matrix for tracking and treating cancer via stimuli-responsive fluorescence on/off with controllable volume transition via a wireless sens...
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| Veröffentlicht in: | Biomaterials science 2019-11, Vol.7 (11), p.48-4812 |
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| creator | Phuong, Pham Thi My Jhon, Heesauk In, Insik Park, Sung Young |
| description | The reversible volume transition of redox-responsive hydrogels by near-infrared (NIR) irradiation has recently attracted significant attention as a novel therapy matrix for tracking and treating cancer
via
stimuli-responsive fluorescence on/off with controllable volume transition
via
a wireless sensing system. Herein, a NIR-induced redox-sensitive hydrogel was synthesized by blending a hydrogel with IR825-loaded carbon dots (CD) to achieve enhanced mobility of nanoparticles inside a gel network, and reversible volume phase transitions remotely controlled by a smartphone application
via
the induction of different redox environments. The presence of CD-IR825 in the thermosensitive poly(
N
-isopropylacrylamide) hydrogel network imparted fluorescence, electronic and photothermal properties to the hydrogels, which resulted in volume shrinkage behavior of the hydrogel upon exposure to NIR laser irradiation due to the redox-sensitive CDs. Under the NIR on/off cycles, the photothermal temperature, fluorescence, and porous structure were reversed after turning off the NIR laser. The hydrogel responsiveness under GSH and NIR light was studied using a wireless device based on the changes in the resistance graph on a smartphone application, generating a fast and simple method for the investigation of hydrogel properties. The
in vitro
cell viabilities of the MDA-MB cancer cells incubated with the composite hydrogel in the presence of external GSH exhibited a higher photothermal temperature, and the cancer cells were effectively killed after the NIR irradiation. Therefore, the NIR-induced redox-responsive nanocomposite hydrogel prepared herein has potential for use in cancer treatment and will enable the study of nanoparticle motion in hydrogel networks under multiple stimuli
via
a wireless device using a faster and more convenient method.
The reversible volume transition of redox-responsive hydrogels by NIR has attracted attention as novel therapy for tracking and treating cancer
via
stimuli-responsive fluorescence on/off with controllable volume transition
via
wireless system. |
| doi_str_mv | 10.1039/c9bm00734b |
| format | Article |
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via
stimuli-responsive fluorescence on/off with controllable volume transition
via
a wireless sensing system. Herein, a NIR-induced redox-sensitive hydrogel was synthesized by blending a hydrogel with IR825-loaded carbon dots (CD) to achieve enhanced mobility of nanoparticles inside a gel network, and reversible volume phase transitions remotely controlled by a smartphone application
via
the induction of different redox environments. The presence of CD-IR825 in the thermosensitive poly(
N
-isopropylacrylamide) hydrogel network imparted fluorescence, electronic and photothermal properties to the hydrogels, which resulted in volume shrinkage behavior of the hydrogel upon exposure to NIR laser irradiation due to the redox-sensitive CDs. Under the NIR on/off cycles, the photothermal temperature, fluorescence, and porous structure were reversed after turning off the NIR laser. The hydrogel responsiveness under GSH and NIR light was studied using a wireless device based on the changes in the resistance graph on a smartphone application, generating a fast and simple method for the investigation of hydrogel properties. The
in vitro
cell viabilities of the MDA-MB cancer cells incubated with the composite hydrogel in the presence of external GSH exhibited a higher photothermal temperature, and the cancer cells were effectively killed after the NIR irradiation. Therefore, the NIR-induced redox-responsive nanocomposite hydrogel prepared herein has potential for use in cancer treatment and will enable the study of nanoparticle motion in hydrogel networks under multiple stimuli
via
a wireless device using a faster and more convenient method.
The reversible volume transition of redox-responsive hydrogels by NIR has attracted attention as novel therapy for tracking and treating cancer
via
stimuli-responsive fluorescence on/off with controllable volume transition
via
wireless system.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/c9bm00734b</identifier><identifier>PMID: 31528924</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acrylic Resins - chemistry ; Cancer ; Cancer therapies ; Carbon - chemistry ; Carbon dots ; Cell Survival ; Fluorescence ; Humans ; Hydrogels ; Hydrogels - chemistry ; Infrared Rays ; Irradiation ; Isopropylacrylamide ; Molecular Structure ; Nanocomposites ; Nanoparticles ; Near infrared radiation ; Neoplasms - therapy ; Oxidation-Reduction ; Phase transitions ; Phototherapy ; Quantum Dots - chemistry ; Remote control ; Shrinkage ; Smartphones ; Stability ; Stimuli ; Temperature ; Tumor Cells, Cultured ; Wireless networks</subject><ispartof>Biomaterials science, 2019-11, Vol.7 (11), p.48-4812</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-8905e28f6106793c04a2e47f3a64b69ce21c02b4895695eb39539d2ce354d7a73</citedby><cites>FETCH-LOGICAL-c363t-8905e28f6106793c04a2e47f3a64b69ce21c02b4895695eb39539d2ce354d7a73</cites><orcidid>0000-0002-0358-6946 ; 0000-0001-7852-1162 ; 0000-0003-0124-1474 ; 0000-0003-0126-5230</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31528924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phuong, Pham Thi My</creatorcontrib><creatorcontrib>Jhon, Heesauk</creatorcontrib><creatorcontrib>In, Insik</creatorcontrib><creatorcontrib>Park, Sung Young</creatorcontrib><title>Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots</title><title>Biomaterials science</title><addtitle>Biomater Sci</addtitle><description>The reversible volume transition of redox-responsive hydrogels by near-infrared (NIR) irradiation has recently attracted significant attention as a novel therapy matrix for tracking and treating cancer
via
stimuli-responsive fluorescence on/off with controllable volume transition
via
a wireless sensing system. Herein, a NIR-induced redox-sensitive hydrogel was synthesized by blending a hydrogel with IR825-loaded carbon dots (CD) to achieve enhanced mobility of nanoparticles inside a gel network, and reversible volume phase transitions remotely controlled by a smartphone application
via
the induction of different redox environments. The presence of CD-IR825 in the thermosensitive poly(
N
-isopropylacrylamide) hydrogel network imparted fluorescence, electronic and photothermal properties to the hydrogels, which resulted in volume shrinkage behavior of the hydrogel upon exposure to NIR laser irradiation due to the redox-sensitive CDs. Under the NIR on/off cycles, the photothermal temperature, fluorescence, and porous structure were reversed after turning off the NIR laser. The hydrogel responsiveness under GSH and NIR light was studied using a wireless device based on the changes in the resistance graph on a smartphone application, generating a fast and simple method for the investigation of hydrogel properties. The
in vitro
cell viabilities of the MDA-MB cancer cells incubated with the composite hydrogel in the presence of external GSH exhibited a higher photothermal temperature, and the cancer cells were effectively killed after the NIR irradiation. Therefore, the NIR-induced redox-responsive nanocomposite hydrogel prepared herein has potential for use in cancer treatment and will enable the study of nanoparticle motion in hydrogel networks under multiple stimuli
via
a wireless device using a faster and more convenient method.
The reversible volume transition of redox-responsive hydrogels by NIR has attracted attention as novel therapy for tracking and treating cancer
via
stimuli-responsive fluorescence on/off with controllable volume transition
via
wireless system.</description><subject>Acrylic Resins - chemistry</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carbon - chemistry</subject><subject>Carbon dots</subject><subject>Cell Survival</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Infrared Rays</subject><subject>Irradiation</subject><subject>Isopropylacrylamide</subject><subject>Molecular Structure</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Near infrared radiation</subject><subject>Neoplasms - therapy</subject><subject>Oxidation-Reduction</subject><subject>Phase transitions</subject><subject>Phototherapy</subject><subject>Quantum Dots - chemistry</subject><subject>Remote control</subject><subject>Shrinkage</subject><subject>Smartphones</subject><subject>Stability</subject><subject>Stimuli</subject><subject>Temperature</subject><subject>Tumor Cells, Cultured</subject><subject>Wireless networks</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1P3DAQxa0KVBDlwr0oiAtCCnU8jhMf2VWhlUDtoZwjf0zYIGe92M4C_33dLt1KHJiLR3q_92TNI-SoohcVBfnFSD1S2gDXH8g-o7wpecvlznYHukcOY3ygeZpGUlF9JHtQ1ayVjO-T9HPhk08LDKNy5ejt5FRCWwRcY4iDdlisvZtGLFJQyzikwS8L3xdPQ0CHMRaLFxv8PbpY4KjR2ux9GtIiB1j_XAaMK59tayyMCjp7rU_xE9ntlYt4-PoekLurr7_m38qbH9ff55c3pQEBqWwlrZG1vaioaCQYyhVD3vSgBNdCGmSVoUzzVtZC1qhB1iAtMwg1t41q4ICcbXJXwT9OGFM3DtGgc2qJfoodYxIoBU4ho6dv0Ac_hWX-Xccgn1cI3raZOt9QJvgYA_bdKgyjCi9dRbs_dXRzObv9W8csw8evkZMe0W7Rf8fPwOcNEKLZqv_7zPrJe3q3sj38BgNrm2M</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Phuong, Pham Thi My</creator><creator>Jhon, Heesauk</creator><creator>In, Insik</creator><creator>Park, Sung Young</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0358-6946</orcidid><orcidid>https://orcid.org/0000-0001-7852-1162</orcidid><orcidid>https://orcid.org/0000-0003-0124-1474</orcidid><orcidid>https://orcid.org/0000-0003-0126-5230</orcidid></search><sort><creationdate>20191101</creationdate><title>Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots</title><author>Phuong, Pham Thi My ; Jhon, Heesauk ; In, Insik ; Park, Sung Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-8905e28f6106793c04a2e47f3a64b69ce21c02b4895695eb39539d2ce354d7a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acrylic Resins - chemistry</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carbon - chemistry</topic><topic>Carbon dots</topic><topic>Cell Survival</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Infrared Rays</topic><topic>Irradiation</topic><topic>Isopropylacrylamide</topic><topic>Molecular Structure</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>Near infrared radiation</topic><topic>Neoplasms - therapy</topic><topic>Oxidation-Reduction</topic><topic>Phase transitions</topic><topic>Phototherapy</topic><topic>Quantum Dots - chemistry</topic><topic>Remote control</topic><topic>Shrinkage</topic><topic>Smartphones</topic><topic>Stability</topic><topic>Stimuli</topic><topic>Temperature</topic><topic>Tumor Cells, Cultured</topic><topic>Wireless networks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phuong, Pham Thi My</creatorcontrib><creatorcontrib>Jhon, Heesauk</creatorcontrib><creatorcontrib>In, Insik</creatorcontrib><creatorcontrib>Park, Sung Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phuong, Pham Thi My</au><au>Jhon, Heesauk</au><au>In, Insik</au><au>Park, Sung Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>7</volume><issue>11</issue><spage>48</spage><epage>4812</epage><pages>48-4812</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>The reversible volume transition of redox-responsive hydrogels by near-infrared (NIR) irradiation has recently attracted significant attention as a novel therapy matrix for tracking and treating cancer
via
stimuli-responsive fluorescence on/off with controllable volume transition
via
a wireless sensing system. Herein, a NIR-induced redox-sensitive hydrogel was synthesized by blending a hydrogel with IR825-loaded carbon dots (CD) to achieve enhanced mobility of nanoparticles inside a gel network, and reversible volume phase transitions remotely controlled by a smartphone application
via
the induction of different redox environments. The presence of CD-IR825 in the thermosensitive poly(
N
-isopropylacrylamide) hydrogel network imparted fluorescence, electronic and photothermal properties to the hydrogels, which resulted in volume shrinkage behavior of the hydrogel upon exposure to NIR laser irradiation due to the redox-sensitive CDs. Under the NIR on/off cycles, the photothermal temperature, fluorescence, and porous structure were reversed after turning off the NIR laser. The hydrogel responsiveness under GSH and NIR light was studied using a wireless device based on the changes in the resistance graph on a smartphone application, generating a fast and simple method for the investigation of hydrogel properties. The
in vitro
cell viabilities of the MDA-MB cancer cells incubated with the composite hydrogel in the presence of external GSH exhibited a higher photothermal temperature, and the cancer cells were effectively killed after the NIR irradiation. Therefore, the NIR-induced redox-responsive nanocomposite hydrogel prepared herein has potential for use in cancer treatment and will enable the study of nanoparticle motion in hydrogel networks under multiple stimuli
via
a wireless device using a faster and more convenient method.
The reversible volume transition of redox-responsive hydrogels by NIR has attracted attention as novel therapy for tracking and treating cancer
via
stimuli-responsive fluorescence on/off with controllable volume transition
via
wireless system.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31528924</pmid><doi>10.1039/c9bm00734b</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0358-6946</orcidid><orcidid>https://orcid.org/0000-0001-7852-1162</orcidid><orcidid>https://orcid.org/0000-0003-0124-1474</orcidid><orcidid>https://orcid.org/0000-0003-0126-5230</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-4830 |
| ispartof | Biomaterials science, 2019-11, Vol.7 (11), p.48-4812 |
| issn | 2047-4830 2047-4849 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C9BM00734B |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Acrylic Resins - chemistry Cancer Cancer therapies Carbon - chemistry Carbon dots Cell Survival Fluorescence Humans Hydrogels Hydrogels - chemistry Infrared Rays Irradiation Isopropylacrylamide Molecular Structure Nanocomposites Nanoparticles Near infrared radiation Neoplasms - therapy Oxidation-Reduction Phase transitions Phototherapy Quantum Dots - chemistry Remote control Shrinkage Smartphones Stability Stimuli Temperature Tumor Cells, Cultured Wireless networks |
| title | Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots |
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