A high-sensitive sensor with HEPES-enhanced electrochemiluminescence of benzo[3]uril for Fe 3+ and its application in human serum

A high-sensitive sensor with HEPES-enhanced electrochemiluminescence of benzo[3]uril for Fe 3+ and its application in human serum

An electrochemiluminescence (ECL) sensor based on a benzo[3]uril-modified glassy carbon electrode with sensitized luminescence, with the coexistence of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) as the coreactant, was successfully constructed. The sensitization mechanism was proposed...

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Veröffentlicht in:Analyst (London) 2020-03, Vol.145 (5), p.1810-1816
Hauptverfasser: Lei, Yao, Qiu, Fei, Jin, Xian-Yi, Yang, Jian-Mei, Liu, Mao, Ge, Qing-Mei, Cong, Hang, Tao, Zhu
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container_issue 5
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container_title Analyst (London)
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creator Lei, Yao
Qiu, Fei
Jin, Xian-Yi
Yang, Jian-Mei
Liu, Mao
Ge, Qing-Mei
Cong, Hang
Tao, Zhu
description An electrochemiluminescence (ECL) sensor based on a benzo[3]uril-modified glassy carbon electrode with sensitized luminescence, with the coexistence of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) as the coreactant, was successfully constructed. The sensitization mechanism was proposed by analyzing the results of the control experiments for establishing the relationship of the luminescence effect with the concentration of HEPES. Under the optimized conditions, the fabricated sensor system was applied for the detection of Fe in an aqueous solution with good sensitivity and selectivity. A low detection limit of 0.41 nM was achieved, indicating superior sensor performance over the previous analytical methods. The ECL sensor system was employed for the detection of Fe in human serum samples to produce excellent recoveries ranging from 96.17% to 101.81%.
doi_str_mv 10.1039/c9an02156f
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source Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title A high-sensitive sensor with HEPES-enhanced electrochemiluminescence of benzo[3]uril for Fe 3+ and its application in human serum
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