Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity

For more than 40 years, protein-polymer conjugates have been widely used for many applications, industrially and biomedically. These bioconjugates have been shown to modulate the activity and stability of various proteins while introducing reusability and new activities that can be used for drug del...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Polymer chemistry 2019-01, Vol.1 (4), p.434-454
Hauptverfasser: Wright, Thaiesha A, Page, Richard C, Konkolewicz, Dominik
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 454
container_issue 4
container_start_page 434
container_title Polymer chemistry
container_volume 1
creator Wright, Thaiesha A
Page, Richard C
Konkolewicz, Dominik
description For more than 40 years, protein-polymer conjugates have been widely used for many applications, industrially and biomedically. These bioconjugates have been shown to modulate the activity and stability of various proteins while introducing reusability and new activities that can be used for drug delivery, and to improve pharmacokinetic ability and stimuli-responsiveness. Techniques such as RDRP, ROMP and "click" have routinely been utilized for the development of well-defined bioconjugate and polymeric materials. The synthesis of bioconjugate materials often takes advantage of the natural amino acids present within the protein and peptide structures for a host of coupling chemistries. Polymer modification may elicit increased or decreased activity, activity retention under harsh conditions, and prolonged activity in vivo and in vitro , and introduce stimuli responsiveness. Bioconjugation has resulted in modulated thermal stability, chemical stability, storage stability, half-life and reusability. In this review we aim to provide a brief account of the field, highlight a wide range of behaviors caused by polymer conjugation, and provide directions for future work. This review article discusses the impact of polymer modification on bioconjugate performance, including both activity and stability, with a focus on how the polymer structure and functionality impact these parameters.
doi_str_mv 10.1039/c8py01399c
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_C8PY01399C</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2250619204</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-c269d7cbfc2c57c9ad2411c288e1fa38cfa8954b5039ff5b03e72481780bba503</originalsourceid><addsrcrecordid>eNpdks9rFTEQx4MottRevCsBL1JYza_NJhdBHlaFgj3owVPIziZtHrubNckW9r839tXnjxDIZOYzXyYzQeg5JW8o4fotqGUjlGsNj9Ap7VrdaC3Z46PdihN0nvOe1MWpYFw-RSecMqElb0_Reh3HbXIJQ5z3640tIc44erykWFyYM7Z147zN5daVAHiJuTQl2TmP96wd8RSH4AMcUkvEYVosFFwTQsK52D6MoWzYzgOu_nBXL8_QE2_H7M4fzjP07fLD192n5urLx8-791cNCKlLA0zqoYPeA4O2A20HJigFppSj3nIF3qr6wL6tjfC-7Ql3HROKdor0va3eM_TuoLus_eQGcHMtfTRLCpNNm4k2mH8jc7g1N_HOyFZLwXQVeP0gkOKP1eVippDBjaOdXVyzYawlkmpGREVf_Yfu45pqgypFpWZSEdFV6uJAQYo5J-ePxVBifg3U7NT19_uB7ir88u_yj-jv8VXgxQFIGY7RPz-C_wTGr6jA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2169268047</pqid></control><display><type>article</type><title>Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Wright, Thaiesha A ; Page, Richard C ; Konkolewicz, Dominik</creator><creatorcontrib>Wright, Thaiesha A ; Page, Richard C ; Konkolewicz, Dominik</creatorcontrib><description>For more than 40 years, protein-polymer conjugates have been widely used for many applications, industrially and biomedically. These bioconjugates have been shown to modulate the activity and stability of various proteins while introducing reusability and new activities that can be used for drug delivery, and to improve pharmacokinetic ability and stimuli-responsiveness. Techniques such as RDRP, ROMP and "click" have routinely been utilized for the development of well-defined bioconjugate and polymeric materials. The synthesis of bioconjugate materials often takes advantage of the natural amino acids present within the protein and peptide structures for a host of coupling chemistries. Polymer modification may elicit increased or decreased activity, activity retention under harsh conditions, and prolonged activity in vivo and in vitro , and introduce stimuli responsiveness. Bioconjugation has resulted in modulated thermal stability, chemical stability, storage stability, half-life and reusability. In this review we aim to provide a brief account of the field, highlight a wide range of behaviors caused by polymer conjugation, and provide directions for future work. This review article discusses the impact of polymer modification on bioconjugate performance, including both activity and stability, with a focus on how the polymer structure and functionality impact these parameters.</description><identifier>ISSN: 1759-9954</identifier><identifier>EISSN: 1759-9962</identifier><identifier>DOI: 10.1039/c8py01399c</identifier><identifier>PMID: 31249635</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Amino acids ; Biomedical materials ; Chemical synthesis ; Conjugation ; Drug delivery systems ; Organic chemistry ; Pharmacology ; Polymer chemistry ; Polymers ; Proteins ; Stimuli ; Storage stability ; Thermal stability</subject><ispartof>Polymer chemistry, 2019-01, Vol.1 (4), p.434-454</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-c269d7cbfc2c57c9ad2411c288e1fa38cfa8954b5039ff5b03e72481780bba503</citedby><cites>FETCH-LOGICAL-c469t-c269d7cbfc2c57c9ad2411c288e1fa38cfa8954b5039ff5b03e72481780bba503</cites><orcidid>0000-0002-3828-5481 ; 0000-0002-3006-3171</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31249635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wright, Thaiesha A</creatorcontrib><creatorcontrib>Page, Richard C</creatorcontrib><creatorcontrib>Konkolewicz, Dominik</creatorcontrib><title>Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity</title><title>Polymer chemistry</title><addtitle>Polym Chem</addtitle><description>For more than 40 years, protein-polymer conjugates have been widely used for many applications, industrially and biomedically. These bioconjugates have been shown to modulate the activity and stability of various proteins while introducing reusability and new activities that can be used for drug delivery, and to improve pharmacokinetic ability and stimuli-responsiveness. Techniques such as RDRP, ROMP and "click" have routinely been utilized for the development of well-defined bioconjugate and polymeric materials. The synthesis of bioconjugate materials often takes advantage of the natural amino acids present within the protein and peptide structures for a host of coupling chemistries. Polymer modification may elicit increased or decreased activity, activity retention under harsh conditions, and prolonged activity in vivo and in vitro , and introduce stimuli responsiveness. Bioconjugation has resulted in modulated thermal stability, chemical stability, storage stability, half-life and reusability. In this review we aim to provide a brief account of the field, highlight a wide range of behaviors caused by polymer conjugation, and provide directions for future work. This review article discusses the impact of polymer modification on bioconjugate performance, including both activity and stability, with a focus on how the polymer structure and functionality impact these parameters.</description><subject>Amino acids</subject><subject>Biomedical materials</subject><subject>Chemical synthesis</subject><subject>Conjugation</subject><subject>Drug delivery systems</subject><subject>Organic chemistry</subject><subject>Pharmacology</subject><subject>Polymer chemistry</subject><subject>Polymers</subject><subject>Proteins</subject><subject>Stimuli</subject><subject>Storage stability</subject><subject>Thermal stability</subject><issn>1759-9954</issn><issn>1759-9962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdks9rFTEQx4MottRevCsBL1JYza_NJhdBHlaFgj3owVPIziZtHrubNckW9r839tXnjxDIZOYzXyYzQeg5JW8o4fotqGUjlGsNj9Ap7VrdaC3Z46PdihN0nvOe1MWpYFw-RSecMqElb0_Reh3HbXIJQ5z3640tIc44erykWFyYM7Z147zN5daVAHiJuTQl2TmP96wd8RSH4AMcUkvEYVosFFwTQsK52D6MoWzYzgOu_nBXL8_QE2_H7M4fzjP07fLD192n5urLx8-791cNCKlLA0zqoYPeA4O2A20HJigFppSj3nIF3qr6wL6tjfC-7Ql3HROKdor0va3eM_TuoLus_eQGcHMtfTRLCpNNm4k2mH8jc7g1N_HOyFZLwXQVeP0gkOKP1eVippDBjaOdXVyzYawlkmpGREVf_Yfu45pqgypFpWZSEdFV6uJAQYo5J-ePxVBifg3U7NT19_uB7ir88u_yj-jv8VXgxQFIGY7RPz-C_wTGr6jA</recordid><startdate>20190128</startdate><enddate>20190128</enddate><creator>Wright, Thaiesha A</creator><creator>Page, Richard C</creator><creator>Konkolewicz, Dominik</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3828-5481</orcidid><orcidid>https://orcid.org/0000-0002-3006-3171</orcidid></search><sort><creationdate>20190128</creationdate><title>Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity</title><author>Wright, Thaiesha A ; Page, Richard C ; Konkolewicz, Dominik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-c269d7cbfc2c57c9ad2411c288e1fa38cfa8954b5039ff5b03e72481780bba503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Amino acids</topic><topic>Biomedical materials</topic><topic>Chemical synthesis</topic><topic>Conjugation</topic><topic>Drug delivery systems</topic><topic>Organic chemistry</topic><topic>Pharmacology</topic><topic>Polymer chemistry</topic><topic>Polymers</topic><topic>Proteins</topic><topic>Stimuli</topic><topic>Storage stability</topic><topic>Thermal stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, Thaiesha A</creatorcontrib><creatorcontrib>Page, Richard C</creatorcontrib><creatorcontrib>Konkolewicz, Dominik</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymer chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, Thaiesha A</au><au>Page, Richard C</au><au>Konkolewicz, Dominik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity</atitle><jtitle>Polymer chemistry</jtitle><addtitle>Polym Chem</addtitle><date>2019-01-28</date><risdate>2019</risdate><volume>1</volume><issue>4</issue><spage>434</spage><epage>454</epage><pages>434-454</pages><issn>1759-9954</issn><eissn>1759-9962</eissn><abstract>For more than 40 years, protein-polymer conjugates have been widely used for many applications, industrially and biomedically. These bioconjugates have been shown to modulate the activity and stability of various proteins while introducing reusability and new activities that can be used for drug delivery, and to improve pharmacokinetic ability and stimuli-responsiveness. Techniques such as RDRP, ROMP and "click" have routinely been utilized for the development of well-defined bioconjugate and polymeric materials. The synthesis of bioconjugate materials often takes advantage of the natural amino acids present within the protein and peptide structures for a host of coupling chemistries. Polymer modification may elicit increased or decreased activity, activity retention under harsh conditions, and prolonged activity in vivo and in vitro , and introduce stimuli responsiveness. Bioconjugation has resulted in modulated thermal stability, chemical stability, storage stability, half-life and reusability. In this review we aim to provide a brief account of the field, highlight a wide range of behaviors caused by polymer conjugation, and provide directions for future work. This review article discusses the impact of polymer modification on bioconjugate performance, including both activity and stability, with a focus on how the polymer structure and functionality impact these parameters.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31249635</pmid><doi>10.1039/c8py01399c</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-3828-5481</orcidid><orcidid>https://orcid.org/0000-0002-3006-3171</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1759-9954
ispartof Polymer chemistry, 2019-01, Vol.1 (4), p.434-454
issn 1759-9954
1759-9962
language eng
recordid cdi_crossref_primary_10_1039_C8PY01399C
source Royal Society Of Chemistry Journals 2008-
subjects Amino acids
Biomedical materials
Chemical synthesis
Conjugation
Drug delivery systems
Organic chemistry
Pharmacology
Polymer chemistry
Polymers
Proteins
Stimuli
Storage stability
Thermal stability
title Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A32%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polymer%20conjugation%20of%20proteins%20as%20a%20synthetic%20post-translational%20modification%20to%20impact%20their%20stability%20and%20activity&rft.jtitle=Polymer%20chemistry&rft.au=Wright,%20Thaiesha%20A&rft.date=2019-01-28&rft.volume=1&rft.issue=4&rft.spage=434&rft.epage=454&rft.pages=434-454&rft.issn=1759-9954&rft.eissn=1759-9962&rft_id=info:doi/10.1039/c8py01399c&rft_dat=%3Cproquest_cross%3E2250619204%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2169268047&rft_id=info:pmid/31249635&rfr_iscdi=true