Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well...

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Veröffentlicht in:Organic & biomolecular chemistry 2019-02, Vol.17 (7), p.1624-1633
Hauptverfasser: Duecker, Fenja L, Reuß, Franziska, Heretsch, Philipp
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Sprache:eng
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Biological properties
Natural products
Organic chemistry
Steroid hormones
Steroids
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container_title Organic & biomolecular chemistry
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creator Duecker, Fenja L
Reuß, Franziska
Heretsch, Philipp
description Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco- and abeo -steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts. Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.
doi_str_mv 10.1039/c8ob02325e
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Biological properties
Natural products
Organic chemistry
Steroid hormones
Steroids
title Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
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