From pirates and killers: does metabolite diversity drive bacterial competition?
Bacteria engage in numerous collaborative and competitive interactions, which are often mediated by small molecule metabolites. Bacterial competition involves for example the production of compounds that effectively kill or inhibit growth of their neighbours but also the secretion of siderophores th...
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Veröffentlicht in: | Organic & biomolecular chemistry 2018-04, Vol.16 (16), p.2814-2819 |
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creator | Szamosvári, Dávid Rütschlin, Sina Böttcher, Thomas |
description | Bacteria engage in numerous collaborative and competitive interactions, which are often mediated by small molecule metabolites. Bacterial competition involves for example the production of compounds that effectively kill or inhibit growth of their neighbours but also the secretion of siderophores that allow securing the essential and fiercely embattled resource of ferric iron. Yet, the enormous diversity of metabolites produced has remained puzzling in many cases. We here present examples of both types of competition from our recent work. These include the human pathogen
Pseudomonas aeruginosa
producing HQNO derived 4-quinolone
N
-oxides varying in chain length and saturation as antibiotics against
Staphylococcus aureus
and two marine bacteria,
Shewanella algae
and
Vibrio alginolyticus
competing for iron acquisition
via
homodimeric and heterodimeric cyclic hydroxamate siderophores. In each case, bacteria not only produce one but a whole set of closely related metabolites encoded by a single biosynthetic gene cluster. Our recent work has demonstrated that individual metabolites can have significantly different biological activities and we speculate on the reasons for maintaining this metabolite diversity from the perspective of interspecies competition.
This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities. |
doi_str_mv | 10.1039/c8ob00150b |
format | Article |
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Pseudomonas aeruginosa
producing HQNO derived 4-quinolone
N
-oxides varying in chain length and saturation as antibiotics against
Staphylococcus aureus
and two marine bacteria,
Shewanella algae
and
Vibrio alginolyticus
competing for iron acquisition
via
homodimeric and heterodimeric cyclic hydroxamate siderophores. In each case, bacteria not only produce one but a whole set of closely related metabolites encoded by a single biosynthetic gene cluster. Our recent work has demonstrated that individual metabolites can have significantly different biological activities and we speculate on the reasons for maintaining this metabolite diversity from the perspective of interspecies competition.
This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/c8ob00150b</identifier><identifier>PMID: 29542773</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Algae ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacteria ; Competition ; Humans ; Iron ; Iron - metabolism ; Metabolites ; Microbial Interactions ; N-Oxides ; Oxides ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - metabolism ; Secretion ; Shewanella - metabolism ; Siderophores ; Siderophores - metabolism ; Staphylococcal Infections - drug therapy ; Staphylococcus aureus - metabolism ; Vibrio alginolyticus - metabolism ; Waterborne diseases</subject><ispartof>Organic & biomolecular chemistry, 2018-04, Vol.16 (16), p.2814-2819</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-943fa941a20ff36c15c2613a002c3bcc7a0330102ea33bfb9ff801264bde7dd33</citedby><cites>FETCH-LOGICAL-c337t-943fa941a20ff36c15c2613a002c3bcc7a0330102ea33bfb9ff801264bde7dd33</cites><orcidid>0000-0003-0235-4825</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29542773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szamosvári, Dávid</creatorcontrib><creatorcontrib>Rütschlin, Sina</creatorcontrib><creatorcontrib>Böttcher, Thomas</creatorcontrib><title>From pirates and killers: does metabolite diversity drive bacterial competition?</title><title>Organic & biomolecular chemistry</title><addtitle>Org Biomol Chem</addtitle><description>Bacteria engage in numerous collaborative and competitive interactions, which are often mediated by small molecule metabolites. Bacterial competition involves for example the production of compounds that effectively kill or inhibit growth of their neighbours but also the secretion of siderophores that allow securing the essential and fiercely embattled resource of ferric iron. Yet, the enormous diversity of metabolites produced has remained puzzling in many cases. We here present examples of both types of competition from our recent work. These include the human pathogen
Pseudomonas aeruginosa
producing HQNO derived 4-quinolone
N
-oxides varying in chain length and saturation as antibiotics against
Staphylococcus aureus
and two marine bacteria,
Shewanella algae
and
Vibrio alginolyticus
competing for iron acquisition
via
homodimeric and heterodimeric cyclic hydroxamate siderophores. In each case, bacteria not only produce one but a whole set of closely related metabolites encoded by a single biosynthetic gene cluster. Our recent work has demonstrated that individual metabolites can have significantly different biological activities and we speculate on the reasons for maintaining this metabolite diversity from the perspective of interspecies competition.
This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.</description><subject>Algae</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Competition</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Metabolites</subject><subject>Microbial Interactions</subject><subject>N-Oxides</subject><subject>Oxides</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - metabolism</subject><subject>Secretion</subject><subject>Shewanella - metabolism</subject><subject>Siderophores</subject><subject>Siderophores - metabolism</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcus aureus - metabolism</subject><subject>Vibrio alginolyticus - metabolism</subject><subject>Waterborne diseases</subject><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0cFKAzEQBuAgiq3Vi3dlwYsI1Ulmu2m8iC1WhUI96HlJsllI3W1qkgp9e6OtFTzNMPkYhj-EnFK4poDiRg-dAqADUHukS3PO-zBAsb_rGXTIUQjzZAQv8kPSYWKQM86xS14m3rXZ0noZTcjkosrebdMYH26zyqVJa6JUrrHRZJX9THMb11nlU5spqaPxVjaZdu3SRButW9wdk4NaNsGcbGuPvE0eXsdP_ens8Xl8P-1rRB77IsdaipxKBnWNhaYDzQqKEoBpVFpzCYhAgRmJqGol6noIlBW5qgyvKsQeudzsXXr3sTIhlq0N2jSNXBi3CiUDmtMcgbFEL_7RuVv5RbouKaRMcDEskrraKO1dCN7U5dLbVvp1SaH8zrkcD2ejn5xHCZ9vV65Ua6od_Q02gbMN8EHvXv8-Cr8A7nCBWA</recordid><startdate>20180425</startdate><enddate>20180425</enddate><creator>Szamosvári, Dávid</creator><creator>Rütschlin, Sina</creator><creator>Böttcher, Thomas</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0235-4825</orcidid></search><sort><creationdate>20180425</creationdate><title>From pirates and killers: does metabolite diversity drive bacterial competition?</title><author>Szamosvári, Dávid ; Rütschlin, Sina ; Böttcher, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-943fa941a20ff36c15c2613a002c3bcc7a0330102ea33bfb9ff801264bde7dd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Algae</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Competition</topic><topic>Humans</topic><topic>Iron</topic><topic>Iron - metabolism</topic><topic>Metabolites</topic><topic>Microbial Interactions</topic><topic>N-Oxides</topic><topic>Oxides</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - metabolism</topic><topic>Secretion</topic><topic>Shewanella - metabolism</topic><topic>Siderophores</topic><topic>Siderophores - metabolism</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcus aureus - metabolism</topic><topic>Vibrio alginolyticus - metabolism</topic><topic>Waterborne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szamosvári, Dávid</creatorcontrib><creatorcontrib>Rütschlin, Sina</creatorcontrib><creatorcontrib>Böttcher, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szamosvári, Dávid</au><au>Rütschlin, Sina</au><au>Böttcher, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From pirates and killers: does metabolite diversity drive bacterial competition?</atitle><jtitle>Organic & biomolecular chemistry</jtitle><addtitle>Org Biomol Chem</addtitle><date>2018-04-25</date><risdate>2018</risdate><volume>16</volume><issue>16</issue><spage>2814</spage><epage>2819</epage><pages>2814-2819</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>Bacteria engage in numerous collaborative and competitive interactions, which are often mediated by small molecule metabolites. Bacterial competition involves for example the production of compounds that effectively kill or inhibit growth of their neighbours but also the secretion of siderophores that allow securing the essential and fiercely embattled resource of ferric iron. Yet, the enormous diversity of metabolites produced has remained puzzling in many cases. We here present examples of both types of competition from our recent work. These include the human pathogen
Pseudomonas aeruginosa
producing HQNO derived 4-quinolone
N
-oxides varying in chain length and saturation as antibiotics against
Staphylococcus aureus
and two marine bacteria,
Shewanella algae
and
Vibrio alginolyticus
competing for iron acquisition
via
homodimeric and heterodimeric cyclic hydroxamate siderophores. In each case, bacteria not only produce one but a whole set of closely related metabolites encoded by a single biosynthetic gene cluster. Our recent work has demonstrated that individual metabolites can have significantly different biological activities and we speculate on the reasons for maintaining this metabolite diversity from the perspective of interspecies competition.
This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29542773</pmid><doi>10.1039/c8ob00150b</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0235-4825</orcidid></addata></record> |
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source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
subjects | Algae Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Competition Humans Iron Iron - metabolism Metabolites Microbial Interactions N-Oxides Oxides Pseudomonas aeruginosa Pseudomonas aeruginosa - metabolism Secretion Shewanella - metabolism Siderophores Siderophores - metabolism Staphylococcal Infections - drug therapy Staphylococcus aureus - metabolism Vibrio alginolyticus - metabolism Waterborne diseases |
title | From pirates and killers: does metabolite diversity drive bacterial competition? |
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