Enhancing tumor chemotherapy and overcoming drug resistance through autophagy-mediated intracellular dissolution of zinc oxide nanoparticles

Autophagy may represent a common cellular response to nanomaterials. In the present study, it was demonstrated that zinc oxide nanoparticle (ZON)-elicited autophagy contributes to tumor cell killing by accelerating the intracellular dissolution of ZONs and reactive oxygen species (ROS) generation. I...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nanoscale 2019-06, Vol.11 (24), p.11789-1187
Hauptverfasser:	Hu, Yi, Zhang, Hou-Rui, Dong, Liang, Xu, Meng-Ran, Zhang, Li, Ding, Wei-Ping, Zhang, Ji-Qian, Lin, Jun, Zhang, Yun-Jiao, Qiu, Ben-Sheng, Wei, Peng-Fei, Wen, Long-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Autophagic Cell Death - drug effects Autophagy Biocompatibility Cancer Cell death Chelation Chemotherapy Dissolution Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacology Drug resistance Drug Resistance, Neoplasm - drug effects Ethylenediaminetetraacetic acids Female HeLa Cells Humans MCF-7 Cells Mice Mice, Inbred BALB C Nanomaterials Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Organic chemistry Reactive Oxygen Species - metabolism Toxicity Tumors Zinc oxide Zinc Oxide - chemistry Zinc Oxide - pharmacology Zinc oxides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!