Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins
In this work, a novel strategy is developed for the fabrication of phenylboronic acid functionalized iron oxide magnetic nanoparticles (MNPs) via distillation-precipitation polymerization and thiol-yne click chemistry. Firstly, silica was coated on the Fe 3 O 4 MNPs using a sol-gel method to obtain...
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| Veröffentlicht in: | New journal of chemistry 2018-10, Vol.42 (21), p.17331-17338 |
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| creator | Bi, Changfen Zhang, Sitong Li, Yiliang He, Xiwen Chen, Langxing Zhang, Yukui |
| description | In this work, a novel strategy is developed for the fabrication of phenylboronic acid functionalized iron oxide magnetic nanoparticles (MNPs)
via
distillation-precipitation polymerization and thiol-yne click chemistry. Firstly, silica was coated on the Fe
3
O
4
MNPs using a sol-gel method to obtain Fe
3
O
4
@SiO
2
. Subsequently, the vinyl groups were grated onto the silica-modified Fe
3
O
4
surface using 3-methacryloyloxypropyltrimethoxysilane. Next, alkynyl groups as the clickable sites were modified on the MNPs to obtain the product Fe
3
O
4
@pPMA
via
distillation-precipitation polymerization of the vinyl end groups with propargyl methacrylate, ethylene glycol dimethacrylate. Finally, phenylboronic acid was grafted on the surface of Fe
3
O
4
@pPMA
via
thiol-yne click chemistry. The morphology, structure, and composition of all the synthesized phenylboronic acid functionalized Fe
3
O
4
MNPs (Fe
3
O
4
@pPMA-MPBA) were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), vibrating sample magnetometry (VSM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Three glycoproteins ovalbumin, transferrin, and horseradish peroxidase and two non-glycoproteins lysozyme and horse heart cytochrome are the chosen target proteins and their adsorption performance on Fe
3
O
4
@pPMA-MPBA is investigated. The Fe
3
O
4
@pPMA-MPBA MNPs exhibited outstanding advantages towards glycoproteins including high adsorption capacity, excellent specificity, repeatability and good enrichment recovery. Furthermore, the Fe
3
O
4
@pPMA-MPBA MNPs could efficiently enrich glycoproteins from real egg white samples. This study provides a feasible strategy for the surface functionalization of boronate affinity nanomaterials for the selective isolation and enrichment of glycoproteins.
Synthesis of phenylboronic acid functionalized iron oxide nanoparticles for glycoprotein enrichment
via
distillation-precipitation polymerization combined with thiol-yne click chemistry. |
| doi_str_mv | 10.1039/c8nj01711e |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_C8NJ01711E</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2123861921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-f275e4d11863cc857325aa6390724c32e594fc930115d642c70992f575a4ec453</originalsourceid><addsrcrecordid>eNp9kUtv1TAQhSMEEqWwYV_JFbtKAT-TeEmvyksVbGAdWZNxr28dO7V9q6b_if-I24vKjtXM0flmRprTNG8Zfc-o0B9gCDvKesbwWXPERKdbzTv2vPZMypYq2b1sXuW8o5SxvmNHze_zmGJwQAy4qbX7AMXFYLy7x4m4apF45yYks7kKWCoXTIiLSbX1mMmtM2RyuTjvzcNguyQEt7jyqMgS_TpjcvcHacJEytZF364BCXgH1wS2ONcFaSU2puoiwZAcbGcMhURLrvwKcUmxoAv5dfPCGp_xzd963Pz6dPFz86W9_PH56-bjZQuC9qW1vFcoJ8aGTgAMqhdcGdMJTXsuQXBUWlrQoj5BTZ3k0FOtuVW9MhJBKnHcvDvsrYdv9pjLuIv7VN-SR864GDqmOavU2YGCFHNOaMcludmkdWR0fIhj3Azfvz3GcVHh0wOcMjxx_-Ial8lW5uR_jPgDqKOXIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2123861921</pqid></control><display><type>article</type><title>Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Bi, Changfen ; Zhang, Sitong ; Li, Yiliang ; He, Xiwen ; Chen, Langxing ; Zhang, Yukui</creator><creatorcontrib>Bi, Changfen ; Zhang, Sitong ; Li, Yiliang ; He, Xiwen ; Chen, Langxing ; Zhang, Yukui</creatorcontrib><description>In this work, a novel strategy is developed for the fabrication of phenylboronic acid functionalized iron oxide magnetic nanoparticles (MNPs)
via
distillation-precipitation polymerization and thiol-yne click chemistry. Firstly, silica was coated on the Fe
3
O
4
MNPs using a sol-gel method to obtain Fe
3
O
4
@SiO
2
. Subsequently, the vinyl groups were grated onto the silica-modified Fe
3
O
4
surface using 3-methacryloyloxypropyltrimethoxysilane. Next, alkynyl groups as the clickable sites were modified on the MNPs to obtain the product Fe
3
O
4
@pPMA
via
distillation-precipitation polymerization of the vinyl end groups with propargyl methacrylate, ethylene glycol dimethacrylate. Finally, phenylboronic acid was grafted on the surface of Fe
3
O
4
@pPMA
via
thiol-yne click chemistry. The morphology, structure, and composition of all the synthesized phenylboronic acid functionalized Fe
3
O
4
MNPs (Fe
3
O
4
@pPMA-MPBA) were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), vibrating sample magnetometry (VSM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Three glycoproteins ovalbumin, transferrin, and horseradish peroxidase and two non-glycoproteins lysozyme and horse heart cytochrome are the chosen target proteins and their adsorption performance on Fe
3
O
4
@pPMA-MPBA is investigated. The Fe
3
O
4
@pPMA-MPBA MNPs exhibited outstanding advantages towards glycoproteins including high adsorption capacity, excellent specificity, repeatability and good enrichment recovery. Furthermore, the Fe
3
O
4
@pPMA-MPBA MNPs could efficiently enrich glycoproteins from real egg white samples. This study provides a feasible strategy for the surface functionalization of boronate affinity nanomaterials for the selective isolation and enrichment of glycoproteins.
Synthesis of phenylboronic acid functionalized iron oxide nanoparticles for glycoprotein enrichment
via
distillation-precipitation polymerization combined with thiol-yne click chemistry.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/c8nj01711e</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Acids ; Adsorption ; Albumen ; Chemical precipitation ; Chemical synthesis ; Cytochromes ; Distillation ; Enrichment ; Ethylene glycol ; Feasibility studies ; Fourier transforms ; Glycoproteins ; Infrared spectroscopy ; Iron oxides ; Lysozyme ; Magnetic measurement ; Morphology ; Nanomaterials ; Nanoparticles ; Organic chemistry ; Ovalbumin ; Peroxidase ; Polymerization ; Proteins ; Silicon dioxide ; Transmission electron microscopy ; X ray photoelectron spectroscopy</subject><ispartof>New journal of chemistry, 2018-10, Vol.42 (21), p.17331-17338</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-f275e4d11863cc857325aa6390724c32e594fc930115d642c70992f575a4ec453</citedby><cites>FETCH-LOGICAL-c307t-f275e4d11863cc857325aa6390724c32e594fc930115d642c70992f575a4ec453</cites><orcidid>0000-0002-8616-9207</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Bi, Changfen</creatorcontrib><creatorcontrib>Zhang, Sitong</creatorcontrib><creatorcontrib>Li, Yiliang</creatorcontrib><creatorcontrib>He, Xiwen</creatorcontrib><creatorcontrib>Chen, Langxing</creatorcontrib><creatorcontrib>Zhang, Yukui</creatorcontrib><title>Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins</title><title>New journal of chemistry</title><description>In this work, a novel strategy is developed for the fabrication of phenylboronic acid functionalized iron oxide magnetic nanoparticles (MNPs)
via
distillation-precipitation polymerization and thiol-yne click chemistry. Firstly, silica was coated on the Fe
3
O
4
MNPs using a sol-gel method to obtain Fe
3
O
4
@SiO
2
. Subsequently, the vinyl groups were grated onto the silica-modified Fe
3
O
4
surface using 3-methacryloyloxypropyltrimethoxysilane. Next, alkynyl groups as the clickable sites were modified on the MNPs to obtain the product Fe
3
O
4
@pPMA
via
distillation-precipitation polymerization of the vinyl end groups with propargyl methacrylate, ethylene glycol dimethacrylate. Finally, phenylboronic acid was grafted on the surface of Fe
3
O
4
@pPMA
via
thiol-yne click chemistry. The morphology, structure, and composition of all the synthesized phenylboronic acid functionalized Fe
3
O
4
MNPs (Fe
3
O
4
@pPMA-MPBA) were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), vibrating sample magnetometry (VSM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Three glycoproteins ovalbumin, transferrin, and horseradish peroxidase and two non-glycoproteins lysozyme and horse heart cytochrome are the chosen target proteins and their adsorption performance on Fe
3
O
4
@pPMA-MPBA is investigated. The Fe
3
O
4
@pPMA-MPBA MNPs exhibited outstanding advantages towards glycoproteins including high adsorption capacity, excellent specificity, repeatability and good enrichment recovery. Furthermore, the Fe
3
O
4
@pPMA-MPBA MNPs could efficiently enrich glycoproteins from real egg white samples. This study provides a feasible strategy for the surface functionalization of boronate affinity nanomaterials for the selective isolation and enrichment of glycoproteins.
Synthesis of phenylboronic acid functionalized iron oxide nanoparticles for glycoprotein enrichment
via
distillation-precipitation polymerization combined with thiol-yne click chemistry.</description><subject>Acids</subject><subject>Adsorption</subject><subject>Albumen</subject><subject>Chemical precipitation</subject><subject>Chemical synthesis</subject><subject>Cytochromes</subject><subject>Distillation</subject><subject>Enrichment</subject><subject>Ethylene glycol</subject><subject>Feasibility studies</subject><subject>Fourier transforms</subject><subject>Glycoproteins</subject><subject>Infrared spectroscopy</subject><subject>Iron oxides</subject><subject>Lysozyme</subject><subject>Magnetic measurement</subject><subject>Morphology</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Organic chemistry</subject><subject>Ovalbumin</subject><subject>Peroxidase</subject><subject>Polymerization</subject><subject>Proteins</subject><subject>Silicon dioxide</subject><subject>Transmission electron microscopy</subject><subject>X ray photoelectron spectroscopy</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1TAQhSMEEqWwYV_JFbtKAT-TeEmvyksVbGAdWZNxr28dO7V9q6b_if-I24vKjtXM0flmRprTNG8Zfc-o0B9gCDvKesbwWXPERKdbzTv2vPZMypYq2b1sXuW8o5SxvmNHze_zmGJwQAy4qbX7AMXFYLy7x4m4apF45yYks7kKWCoXTIiLSbX1mMmtM2RyuTjvzcNguyQEt7jyqMgS_TpjcvcHacJEytZF364BCXgH1wS2ONcFaSU2puoiwZAcbGcMhURLrvwKcUmxoAv5dfPCGp_xzd963Pz6dPFz86W9_PH56-bjZQuC9qW1vFcoJ8aGTgAMqhdcGdMJTXsuQXBUWlrQoj5BTZ3k0FOtuVW9MhJBKnHcvDvsrYdv9pjLuIv7VN-SR864GDqmOavU2YGCFHNOaMcludmkdWR0fIhj3Azfvz3GcVHh0wOcMjxx_-Ial8lW5uR_jPgDqKOXIg</recordid><startdate>20181022</startdate><enddate>20181022</enddate><creator>Bi, Changfen</creator><creator>Zhang, Sitong</creator><creator>Li, Yiliang</creator><creator>He, Xiwen</creator><creator>Chen, Langxing</creator><creator>Zhang, Yukui</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0002-8616-9207</orcidid></search><sort><creationdate>20181022</creationdate><title>Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins</title><author>Bi, Changfen ; Zhang, Sitong ; Li, Yiliang ; He, Xiwen ; Chen, Langxing ; Zhang, Yukui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-f275e4d11863cc857325aa6390724c32e594fc930115d642c70992f575a4ec453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acids</topic><topic>Adsorption</topic><topic>Albumen</topic><topic>Chemical precipitation</topic><topic>Chemical synthesis</topic><topic>Cytochromes</topic><topic>Distillation</topic><topic>Enrichment</topic><topic>Ethylene glycol</topic><topic>Feasibility studies</topic><topic>Fourier transforms</topic><topic>Glycoproteins</topic><topic>Infrared spectroscopy</topic><topic>Iron oxides</topic><topic>Lysozyme</topic><topic>Magnetic measurement</topic><topic>Morphology</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Organic chemistry</topic><topic>Ovalbumin</topic><topic>Peroxidase</topic><topic>Polymerization</topic><topic>Proteins</topic><topic>Silicon dioxide</topic><topic>Transmission electron microscopy</topic><topic>X ray photoelectron spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bi, Changfen</creatorcontrib><creatorcontrib>Zhang, Sitong</creatorcontrib><creatorcontrib>Li, Yiliang</creatorcontrib><creatorcontrib>He, Xiwen</creatorcontrib><creatorcontrib>Chen, Langxing</creatorcontrib><creatorcontrib>Zhang, Yukui</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bi, Changfen</au><au>Zhang, Sitong</au><au>Li, Yiliang</au><au>He, Xiwen</au><au>Chen, Langxing</au><au>Zhang, Yukui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins</atitle><jtitle>New journal of chemistry</jtitle><date>2018-10-22</date><risdate>2018</risdate><volume>42</volume><issue>21</issue><spage>17331</spage><epage>17338</epage><pages>17331-17338</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>In this work, a novel strategy is developed for the fabrication of phenylboronic acid functionalized iron oxide magnetic nanoparticles (MNPs)
via
distillation-precipitation polymerization and thiol-yne click chemistry. Firstly, silica was coated on the Fe
3
O
4
MNPs using a sol-gel method to obtain Fe
3
O
4
@SiO
2
. Subsequently, the vinyl groups were grated onto the silica-modified Fe
3
O
4
surface using 3-methacryloyloxypropyltrimethoxysilane. Next, alkynyl groups as the clickable sites were modified on the MNPs to obtain the product Fe
3
O
4
@pPMA
via
distillation-precipitation polymerization of the vinyl end groups with propargyl methacrylate, ethylene glycol dimethacrylate. Finally, phenylboronic acid was grafted on the surface of Fe
3
O
4
@pPMA
via
thiol-yne click chemistry. The morphology, structure, and composition of all the synthesized phenylboronic acid functionalized Fe
3
O
4
MNPs (Fe
3
O
4
@pPMA-MPBA) were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), vibrating sample magnetometry (VSM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Three glycoproteins ovalbumin, transferrin, and horseradish peroxidase and two non-glycoproteins lysozyme and horse heart cytochrome are the chosen target proteins and their adsorption performance on Fe
3
O
4
@pPMA-MPBA is investigated. The Fe
3
O
4
@pPMA-MPBA MNPs exhibited outstanding advantages towards glycoproteins including high adsorption capacity, excellent specificity, repeatability and good enrichment recovery. Furthermore, the Fe
3
O
4
@pPMA-MPBA MNPs could efficiently enrich glycoproteins from real egg white samples. This study provides a feasible strategy for the surface functionalization of boronate affinity nanomaterials for the selective isolation and enrichment of glycoproteins.
Synthesis of phenylboronic acid functionalized iron oxide nanoparticles for glycoprotein enrichment
via
distillation-precipitation polymerization combined with thiol-yne click chemistry.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/c8nj01711e</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8616-9207</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2018-10, Vol.42 (21), p.17331-17338 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C8NJ01711E |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Acids Adsorption Albumen Chemical precipitation Chemical synthesis Cytochromes Distillation Enrichment Ethylene glycol Feasibility studies Fourier transforms Glycoproteins Infrared spectroscopy Iron oxides Lysozyme Magnetic measurement Morphology Nanomaterials Nanoparticles Organic chemistry Ovalbumin Peroxidase Polymerization Proteins Silicon dioxide Transmission electron microscopy X ray photoelectron spectroscopy |
| title | Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins |
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