Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift
Herein, a fluorescent probe, Dcp-EPtz , for HOCl based on a strong push–pull phenothiazine–dicyanoisophorone conjugate was prepared. The probe exhibits a very large Stokes shift of over 170 nm. Dcp-EPtz turns out to be a fast-responsive (
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Veröffentlicht in: | New journal of chemistry 2018, Vol.42 (7), p.5135-5141 |
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container_title | New journal of chemistry |
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creator | Zheng, Dasheng Qiu, Xiaoying Liu, Chang Jiao, Xiaojie He, Song Zhao, Liancheng Zeng, Xianshun |
description | Herein, a fluorescent probe,
Dcp-EPtz
, for HOCl based on a strong push–pull phenothiazine–dicyanoisophorone conjugate was prepared. The probe exhibits a very large Stokes shift of over 170 nm.
Dcp-EPtz
turns out to be a fast-responsive ( |
doi_str_mv | 10.1039/C8NJ00279G |
format | Article |
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Dcp-EPtz
, for HOCl based on a strong push–pull phenothiazine–dicyanoisophorone conjugate was prepared. The probe exhibits a very large Stokes shift of over 170 nm.
Dcp-EPtz
turns out to be a fast-responsive (<10 s) fluorescent probe for HOCl with high selectivity and sensitivity. It shows a good linear relationship between the enhanced fluorescence intensity at 617 nm and the concentration of hypochlorous acid in the range 0–10 μM, with the detection limit of 3.9 × 10
−8
M. Moreover, the probe
Dcp-EPtz
exhibits the ability for endogenous HOCl monitoring in living cells.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/C8NJ00279G</identifier><language>eng</language><ispartof>New journal of chemistry, 2018, Vol.42 (7), p.5135-5141</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c231t-7ed9894a9e33615a5ee06aeaef292fc15e3f30b6564ec24b0fd5493b8f6d71cc3</citedby><cites>FETCH-LOGICAL-c231t-7ed9894a9e33615a5ee06aeaef292fc15e3f30b6564ec24b0fd5493b8f6d71cc3</cites><orcidid>0000-0001-7761-0198</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Zheng, Dasheng</creatorcontrib><creatorcontrib>Qiu, Xiaoying</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Jiao, Xiaojie</creatorcontrib><creatorcontrib>He, Song</creatorcontrib><creatorcontrib>Zhao, Liancheng</creatorcontrib><creatorcontrib>Zeng, Xianshun</creatorcontrib><title>Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift</title><title>New journal of chemistry</title><description>Herein, a fluorescent probe,
Dcp-EPtz
, for HOCl based on a strong push–pull phenothiazine–dicyanoisophorone conjugate was prepared. The probe exhibits a very large Stokes shift of over 170 nm.
Dcp-EPtz
turns out to be a fast-responsive (<10 s) fluorescent probe for HOCl with high selectivity and sensitivity. It shows a good linear relationship between the enhanced fluorescence intensity at 617 nm and the concentration of hypochlorous acid in the range 0–10 μM, with the detection limit of 3.9 × 10
−8
M. Moreover, the probe
Dcp-EPtz
exhibits the ability for endogenous HOCl monitoring in living cells.</description><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpFkD1OwzAcxS0EEqWwcALPSAE7Tpx6RBW0oAqGwhw5zt-1S7Aj2wWFiTtwC47FSSgFiel96Ok3PIROKTmnhImL6eTulpC8ErM9NKKMi0zknO5vPS2KjJQFP0RHMa4JobTidIQ-l4NLBqKNWLoWN9bLvu-sksl6h73GEhu7Mt2AI3Sgkn2B3TCCi3aXdLfxAaICl3AffLNtfMDz-2mHGxmhxVuOxL0B55Ox8s06-Hr_aK0apPM2-t744B1g5d16s5IJ8KtNBncyrAAvk3-CiKOxOh2jAy27CCd_OkaP11cP03m2uJ_dTC8XmcoZTVkFrZiIQgpgjNNSlgCES5Cgc5FrRUtgmpGGl7wAlRcN0W1ZCNZMNG8rqhQbo7Nfrgo-xgC67oN9lmGoKal_Xq7_X2bfi1J2Dw</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Zheng, Dasheng</creator><creator>Qiu, Xiaoying</creator><creator>Liu, Chang</creator><creator>Jiao, Xiaojie</creator><creator>He, Song</creator><creator>Zhao, Liancheng</creator><creator>Zeng, Xianshun</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-7761-0198</orcidid></search><sort><creationdate>2018</creationdate><title>Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift</title><author>Zheng, Dasheng ; Qiu, Xiaoying ; Liu, Chang ; Jiao, Xiaojie ; He, Song ; Zhao, Liancheng ; Zeng, Xianshun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c231t-7ed9894a9e33615a5ee06aeaef292fc15e3f30b6564ec24b0fd5493b8f6d71cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Dasheng</creatorcontrib><creatorcontrib>Qiu, Xiaoying</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Jiao, Xiaojie</creatorcontrib><creatorcontrib>He, Song</creatorcontrib><creatorcontrib>Zhao, Liancheng</creatorcontrib><creatorcontrib>Zeng, Xianshun</creatorcontrib><collection>CrossRef</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Dasheng</au><au>Qiu, Xiaoying</au><au>Liu, Chang</au><au>Jiao, Xiaojie</au><au>He, Song</au><au>Zhao, Liancheng</au><au>Zeng, Xianshun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift</atitle><jtitle>New journal of chemistry</jtitle><date>2018</date><risdate>2018</risdate><volume>42</volume><issue>7</issue><spage>5135</spage><epage>5141</epage><pages>5135-5141</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>Herein, a fluorescent probe,
Dcp-EPtz
, for HOCl based on a strong push–pull phenothiazine–dicyanoisophorone conjugate was prepared. The probe exhibits a very large Stokes shift of over 170 nm.
Dcp-EPtz
turns out to be a fast-responsive (<10 s) fluorescent probe for HOCl with high selectivity and sensitivity. It shows a good linear relationship between the enhanced fluorescence intensity at 617 nm and the concentration of hypochlorous acid in the range 0–10 μM, with the detection limit of 3.9 × 10
−8
M. Moreover, the probe
Dcp-EPtz
exhibits the ability for endogenous HOCl monitoring in living cells.</abstract><doi>10.1039/C8NJ00279G</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7761-0198</orcidid></addata></record> |
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source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
title | Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift |
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