Antimicrobial glycoconjugate vaccines: an overview of classic and modern approaches for protein modification

Glycoconjugate vaccines obtained by chemical linkage of a carbohydrate antigen to a protein are part of routine vaccinations in many countries. Licensed antimicrobial glycan-protein conjugate vaccines are obtained by random conjugation of native or sized polysaccharides to lysine, aspartic or glutam...

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Veröffentlicht in:	Chemical Society reviews 2018-12, Vol.47 (24), p.915-925
Hauptverfasser:	Berti, Francesco, Adamo, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antigens Antiinfectives and antibacterials Carbohydrates Conjugation Glycan Immunology Lysine Organic chemistry Polysaccharides Proteins Residues State of the art Vaccines
Online-Zugang:	Volltext
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