Templated synthesis of spherical RNA nanoparticles with gene silencing activity

Templated synthesis of spherical RNA nanoparticles with gene silencing activity

RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solu...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-10, Vol.54 (8), p.11296-11299
Hauptverfasser: Dore, Michael D, Fakhoury, Johans J, Lacroix, Aurélie, Sleiman, Hanadi F
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Sprache:eng
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Deoxyribonucleic acid
DNA
Nanoparticles
Ribonucleic acid
RNA
Synthesis
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container_issue 8
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container_title Chemical communications (Cambridge, England)
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creator Dore, Michael D
Fakhoury, Johans J
Lacroix, Aurélie
Sleiman, Hanadi F
description RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solution and show gene silencing activity. Bioactive RNA nanoparticles with gene silencing activity have been synthesized in high yield using a complementary spherical DNA nanoparticle.
doi_str_mv 10.1039/c8cc06994h
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Deoxyribonucleic acid
DNA
Nanoparticles
Ribonucleic acid
RNA
Synthesis
title Templated synthesis of spherical RNA nanoparticles with gene silencing activity
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