CDy14: a novel biofilm probe targeting exopolysaccharide Psl
Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fl...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2018-10, Vol.54 (84), p.11865-11868 |
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| container_issue | 84 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 54 |
| creator | Kwon, Haw-Young Kim, Jun-Young Lee, Jung Yeol Yam, Joey Kuok Hoong Hultqvist, Louise Dahl Xu, Wang Rybtke, Morten Tolker-Nielsen, Tim Kim, Jong-Jin Kang, Nam-Young Yang, Liang Park, Sung-Jin Givskov, Michael Chang, Young-Tae |
| description | Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.
We developed CDy14, which is the first small molecule probe for Psl target in bacterial biofilm. |
| doi_str_mv | 10.1039/c8cc05544k |
| format | Article |
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We developed CDy14, which is the first small molecule probe for Psl target in bacterial biofilm.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c8cc05544k</identifier><identifier>PMID: 30204158</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biofilms ; Fluorescent Dyes - chemistry ; Fluorescent Dyes - metabolism ; Fluorescent indicators ; Microscopy, Fluorescence ; Physicians ; Polysaccharides, Bacterial - chemistry ; Polysaccharides, Bacterial - metabolism ; Pseudomonas aeruginosa - chemistry</subject><ispartof>Chemical communications (Cambridge, England), 2018-10, Vol.54 (84), p.11865-11868</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-388bfc1ee3b36511a762519311cf2955ea3b7d7f74d2f81754c60e24083ec05d3</citedby><cites>FETCH-LOGICAL-c337t-388bfc1ee3b36511a762519311cf2955ea3b7d7f74d2f81754c60e24083ec05d3</cites><orcidid>0000-0002-9751-474X ; 0000-0002-1927-3688</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30204158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Haw-Young</creatorcontrib><creatorcontrib>Kim, Jun-Young</creatorcontrib><creatorcontrib>Lee, Jung Yeol</creatorcontrib><creatorcontrib>Yam, Joey Kuok Hoong</creatorcontrib><creatorcontrib>Hultqvist, Louise Dahl</creatorcontrib><creatorcontrib>Xu, Wang</creatorcontrib><creatorcontrib>Rybtke, Morten</creatorcontrib><creatorcontrib>Tolker-Nielsen, Tim</creatorcontrib><creatorcontrib>Kim, Jong-Jin</creatorcontrib><creatorcontrib>Kang, Nam-Young</creatorcontrib><creatorcontrib>Yang, Liang</creatorcontrib><creatorcontrib>Park, Sung-Jin</creatorcontrib><creatorcontrib>Givskov, Michael</creatorcontrib><creatorcontrib>Chang, Young-Tae</creatorcontrib><title>CDy14: a novel biofilm probe targeting exopolysaccharide Psl</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.
We developed CDy14, which is the first small molecule probe for Psl target in bacterial biofilm.</description><subject>Biofilms</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent Dyes - metabolism</subject><subject>Fluorescent indicators</subject><subject>Microscopy, Fluorescence</subject><subject>Physicians</subject><subject>Polysaccharides, Bacterial - chemistry</subject><subject>Polysaccharides, Bacterial - metabolism</subject><subject>Pseudomonas aeruginosa - chemistry</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c9LwzAUB_AgipvTi3el4EWEapKXtKl4kfoTB3pQ8FbSNJ2dbTOTVtx_b-bmBHPJg3x4vPcNQvsEnxIMyZkSSmHOGXvfQEMCEQs5E6-bi5onYQyMD9COc1PsD-FiGw0AU8x8OUQX6dWcsPNABq351HWQV6as6iaYWZProJN2oruqnQT6y8xMPXdSqTdpq0IHT67eRVulrJ3eW90j9HJz_ZzehePH2_v0chwqgLgLQYi8VERryCHihMg4opwkQIgqacK5lpDHRVzGrKClIDFnKsKaMixA-8UKGKHjZV8_1UevXZc1lVO6rmWrTe8ySjAFGgkAT4_-0anpbeun84oSljAaL9TJUilrnLO6zGa2aqSdZwRni0yzVKTpT6YPHh-uWvZ5o4s1_Q3Rg4MlsE6tX_8-Bb4Boxp4bA</recordid><startdate>20181018</startdate><enddate>20181018</enddate><creator>Kwon, Haw-Young</creator><creator>Kim, Jun-Young</creator><creator>Lee, Jung Yeol</creator><creator>Yam, Joey Kuok Hoong</creator><creator>Hultqvist, Louise Dahl</creator><creator>Xu, Wang</creator><creator>Rybtke, Morten</creator><creator>Tolker-Nielsen, Tim</creator><creator>Kim, Jong-Jin</creator><creator>Kang, Nam-Young</creator><creator>Yang, Liang</creator><creator>Park, Sung-Jin</creator><creator>Givskov, Michael</creator><creator>Chang, Young-Tae</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9751-474X</orcidid><orcidid>https://orcid.org/0000-0002-1927-3688</orcidid></search><sort><creationdate>20181018</creationdate><title>CDy14: a novel biofilm probe targeting exopolysaccharide Psl</title><author>Kwon, Haw-Young ; 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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2018-10, Vol.54 (84), p.11865-11868 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C8CC05544K |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biofilms Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Fluorescent indicators Microscopy, Fluorescence Physicians Polysaccharides, Bacterial - chemistry Polysaccharides, Bacterial - metabolism Pseudomonas aeruginosa - chemistry |
| title | CDy14: a novel biofilm probe targeting exopolysaccharide Psl |
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