ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO)

ESIPT-based fluorescence probes are emerging as an attractive tool for the detection of biologically relevant analytes owing to their unique photophysical properties. In this work, we have developed an ESIPT-based fluorescence probe ( TCBT-OMe ) for the detection of HClO/ClO − through the attachment...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (61), p.8522-8525
Hauptverfasser:	Wu, Luling, Yang, Qingye, Liu, Liyuan, Sedgwick, Adam C, Cresswell, Alexander J, Bull, Steven D, Huang, Chusen, James, Tony D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Drinking water Fluorescent indicators Hydrogen peroxide Logic circuits Mercury (metal)
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container_title	Chemical communications (Cambridge, England)
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creator	Wu, Luling Yang, Qingye Liu, Liyuan Sedgwick, Adam C Cresswell, Alexander J Bull, Steven D Huang, Chusen James, Tony D
description	ESIPT-based fluorescence probes are emerging as an attractive tool for the detection of biologically relevant analytes owing to their unique photophysical properties. In this work, we have developed an ESIPT-based fluorescence probe ( TCBT-OMe ) for the detection of HClO/ClO − through the attachment of a bioorthogonal dimethylthiocarbamate linker. TCBT-OMe was shown to rapidly detect HClO/ClO − (30 min to produce a fluorescence response. Test strips containing TCBT-OMe were prepared and were demonstrated as an effective way to detect HClO/ClO − in water. Furthermore, TCBT-OMe was shown to detect exogenously added HClO/ClO − in three different water samples with little interference thus demonstrating the effectiveness as a method for the detection of HClO/ClO − in drinking water samples. ESIPT-based fluorescence probes are emerging as an attractive tool for the detection of biologically relevant analytes owing to their unique photophysical properties.
doi_str_mv	10.1039/c8cc03717e
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In this work, we have developed an ESIPT-based fluorescence probe ( TCBT-OMe ) for the detection of HClO/ClO − through the attachment of a bioorthogonal dimethylthiocarbamate linker. TCBT-OMe was shown to rapidly detect HClO/ClO − (<10 s) at biologically relevant concentrations (LoD = 0.16 nM) and have an excellent selectivity towards others ROS/RNS and amino acids. Therefore, TCBT-OMe was tested in live cells and was successfully shown to be able to detect endogenous and exogenous HClO/ClO − in HeLa cells. Additionally, TCBT-OMe acts as a dual input logic gate for Hg 2+ and H 2 O 2 . Interestingly, Hg 2+ alone gradually causes a fluorescence response but requires >30 min to produce a fluorescence response. Test strips containing TCBT-OMe were prepared and were demonstrated as an effective way to detect HClO/ClO − in water. Furthermore, TCBT-OMe was shown to detect exogenously added HClO/ClO − in three different water samples with little interference thus demonstrating the effectiveness as a method for the detection of HClO/ClO − in drinking water samples. 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In this work, we have developed an ESIPT-based fluorescence probe ( TCBT-OMe ) for the detection of HClO/ClO − through the attachment of a bioorthogonal dimethylthiocarbamate linker. TCBT-OMe was shown to rapidly detect HClO/ClO − (<10 s) at biologically relevant concentrations (LoD = 0.16 nM) and have an excellent selectivity towards others ROS/RNS and amino acids. Therefore, TCBT-OMe was tested in live cells and was successfully shown to be able to detect endogenous and exogenous HClO/ClO − in HeLa cells. Additionally, TCBT-OMe acts as a dual input logic gate for Hg 2+ and H 2 O 2 . Interestingly, Hg 2+ alone gradually causes a fluorescence response but requires >30 min to produce a fluorescence response. Test strips containing TCBT-OMe were prepared and were demonstrated as an effective way to detect HClO/ClO − in water. Furthermore, TCBT-OMe was shown to detect exogenously added HClO/ClO − in three different water samples with little interference thus demonstrating the effectiveness as a method for the detection of HClO/ClO − in drinking water samples. 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subjects	Amino acids Drinking water Fluorescent indicators Hydrogen peroxide Logic circuits Mercury (metal)
title	ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO)
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