Fischer indole synthesis applied to the total synthesis of natural products
One of the oldest and most useful reactions in organic chemistry is the Fischer indole synthesis (FIS). It is known to have a wide variety of applications including the synthesis of indole rings, often present as the framework in the total synthesis of natural products, particularly those found in t...
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| Veröffentlicht in: | RSC advances 2017-01, Vol.7 (83), p.52852-52887 |
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| creator | Heravi, Majid M Rohani, Sahar Zadsirjan, Vahideh Zahedi, Nazli |
| description | One of the oldest and most useful reactions in organic chemistry is the Fischer indole synthesis (FIS). It is known to have a wide variety of applications including the synthesis of indole rings, often present as the framework in the total synthesis of natural products, particularly those found in the realm of alkaloids, which comprise a ring system known as an indole alkaloid. In this review, we are trying to emphasize the applications of FIS as an old reaction, which is currently applied to the total synthesis of biologically active natural products and some other complex targets.
In this review, we are trying to underscore the application of FIS in one of the crucial step of indole construction in the total synthesis of biologically active natural products. |
| doi_str_mv | 10.1039/c7ra10716a |
| format | Article |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Alkaloids Chemical synthesis Natural products Organic chemistry |
| title | Fischer indole synthesis applied to the total synthesis of natural products |
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