ent-Rosane diterpenoids from Euphorbia milii showing an Epstein–Barr virus lytic replication assay

ent-Rosane diterpenoids from Euphorbia milii showing an Epstein–Barr virus lytic replication assay

The phytochemical investigation on the acetone extract of Euphorbia milii afforded thirteen new ent -rosane diterpenoids ( 1–13 ) through bioassay guided fractionation for evaluating its effect on Epstein–Barr virus (EBV) DNA lytic replication. Structures were determined by comprehensive spectroscop...

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Veröffentlicht in:RSC advances 2017, Vol.7 (74), p.46938-46947
Hauptverfasser: Liu, Shao-Nan, Hu, Jiayuan, Tan, Shen H., Wang, Qian, Xu, Jun, Wang, Yan, Yuan, Yan, Gu, Qiong
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container_end_page 46947
container_issue 74
container_start_page 46938
container_title RSC advances
container_volume 7
creator Liu, Shao-Nan
Hu, Jiayuan
Tan, Shen H.
Wang, Qian
Xu, Jun
Wang, Yan
Yuan, Yan
Gu, Qiong
description The phytochemical investigation on the acetone extract of Euphorbia milii afforded thirteen new ent -rosane diterpenoids ( 1–13 ) through bioassay guided fractionation for evaluating its effect on Epstein–Barr virus (EBV) DNA lytic replication. Structures were determined by comprehensive spectroscopic analyses including 1D & 2D NMR techniques, chemical methods, and experimental and calculated electronic circular dichroism (ECD) data. The absolute configuration of euphominoid A ( 1 ) was established by single crystal X-ray diffraction analysis of its p -bromobenzoate derivative 1a . Compounds 1–3 , and 10 displayed inhibitory activity with EC 50 values ranging from 5.4 to 29.1 μM and selective index (SI) values varied from 4.5 to 9.3. Compound 2 showed the most potent inhibitory activity with an EC 50 value of 5.4 μM comparing with the positive control (+)-rutamarin (EC 50 = 5.4 μM). This is the first report of ent -rosane-type diterpenoids exhibiting significant inhibition of EBV lytic replication.
doi_str_mv 10.1039/C7RA08877A
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title ent-Rosane diterpenoids from Euphorbia milii showing an Epstein–Barr virus lytic replication assay
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