Multimode microsensors based on Ag–TiO 2 –graphene materials used for the molecular recognition of carcinoembryonic antigen in whole blood samples

Multimode microsensors based on Ag–TiO 2 –graphene materials used for the molecular recognition of carcinoembryonic antigen in whole blood samples

Ag–TiO 2 –graphene pastes modified with inulin, and l -alanine tert -butyl ester nitrate ( l -Ala-C 4 - l -Lac), respectively, were proposed for the molecular recognition of carcinoembryonic antigen (CEA) from whole blood samples. High levels of CEA are associated with different types of cancer, one...

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Veröffentlicht in:RSC advances 2017, Vol.7 (45), p.28419-28426
Hauptverfasser: Gugoasa, Livia Alexandra, Muklive AĺOgaidi, Ahmed Jassim, Stefan-van Staden, Raluca-Ioana, El-Khatib, Ahed, Rosu, Marcela-Corina, Pruneanu, Stela
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container_issue 45
container_start_page 28419
container_title RSC advances
container_volume 7
creator Gugoasa, Livia Alexandra
Muklive AĺOgaidi, Ahmed Jassim
Stefan-van Staden, Raluca-Ioana
El-Khatib, Ahed
Rosu, Marcela-Corina
Pruneanu, Stela
description Ag–TiO 2 –graphene pastes modified with inulin, and l -alanine tert -butyl ester nitrate ( l -Ala-C 4 - l -Lac), respectively, were proposed for the molecular recognition of carcinoembryonic antigen (CEA) from whole blood samples. High levels of CEA are associated with different types of cancer, one of them being colorectal cancer. Both sensors gave high reliability for the measurements, and also high sensitivity and selectivity were recorded. The modes used were stochastic mode for qualitative and quantitative analysis of CEA, and differential pulse voltammetry for the quantitative measurement of CEA. The lowest limit of determination (20.5 fg mL −1 ) was recorded when the multimode sensor based on Ag–TiO 2 –graphene paste was modified with the inulin IQ.
doi_str_mv 10.1039/C7RA03842A
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title Multimode microsensors based on Ag–TiO 2 –graphene materials used for the molecular recognition of carcinoembryonic antigen in whole blood samples
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