Anti-HIV activity of new higher order G-quadruplex aptamers obtained from tetra-end-linked oligonucleotides

By combining the ability of short G-rich oligodeoxyribonucleotides (ODNs) containing the sequence 5 ′CGGA 3 ′ to form higher order G-quadruplex (G4) complexes with the tetra-end-linked (TEL) concept to produce aptamers targeting the HIV envelope glycoprotein 120 (gp120), three new TEL-ODNs ( 1-3 ) h...

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Veröffentlicht in:	Organic & biomolecular chemistry 2018-03, Vol.16 (13), p.2349-2355
Hauptverfasser:	Nici, F, Oliviero, G, Falanga, A. P, D'Errico, S, Marzano, M, Musumeci, D, Montesarchio, D, Noppen, S, Pannecouque, C, Piccialli, G, Borbone, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemical synthesis Anti-HIV Agents - metabolism Anti-HIV Agents - pharmacology Antiviral activity Aptamers Aptamers, Nucleotide - chemical synthesis Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Aptamers, Nucleotide - pharmacology Cell Line Dimerization G-Quadruplexes Glycoprotein gp120 Glycoproteins HIV HIV Envelope Protein gp120 - metabolism HIV Infections - prevention & control Human immunodeficiency virus Humans Hydrophobicity Lipophilic Oligodeoxyribonucleotides - chemical synthesis Oligodeoxyribonucleotides - genetics Oligodeoxyribonucleotides - metabolism Oligodeoxyribonucleotides - pharmacology Oligonucleotides Protein Binding
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