Hydroxylation of anilides by engineered cytochrome P450 BM3

Biocatalytic direct monohydroxylation of anilides has been achieved on preparative scale using mutant cytochrome P450 enzymes. Representative mono- and disubstituted N-trifluoromethanesulfonyl anilides are shown to be converted in most cases to the corresponding 4-hydroxy derivatives, with substitue...

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Veröffentlicht in:	Organic & biomolecular chemistry 2017-10, Vol.15 (41), p.8780-8787
Hauptverfasser:	O'Hanlon, Jack A, Ren, Xinkun, Morris, Melloney, Wong, Luet Lok, Robertson, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - chemistry Anilides - metabolism Bacterial Proteins - chemistry Bacterial Proteins - metabolism Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Hydroxylation Molecular Structure NADPH-Ferrihemoprotein Reductase - chemistry NADPH-Ferrihemoprotein Reductase - metabolism Protein Engineering
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