Interaction of Aβ 1-42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy
Toxicity of Aβ peptides involved in Alzheimer's disease is linked to the interaction of intermediate species with membranes. Nanoscale Infrared Spectroscopy enhances the study of the morphology and the secondary structure of the peptides as fibers or oligomers interacting with membranes of diff...
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| Veröffentlicht in: | Nanoscale 2018-01, Vol.10 (3), p.936-940 |
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| container_title | Nanoscale |
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| creator | Henry, S Bercu, N B Bobo, C Cullin, C Molinari, M Lecomte, S |
| description | Toxicity of Aβ peptides involved in Alzheimer's disease is linked to the interaction of intermediate species with membranes. Nanoscale Infrared Spectroscopy enhances the study of the morphology and the secondary structure of the peptides as fibers or oligomers interacting with membranes of different compositions, with nanometer scale resolution. Membrane models are used to investigate the role of different lipids in their interactions with Aβ peptides. This work clearly brings to light that the presence of cholesterol in membranes is favorable to the interaction with Aβ peptides in oligomers or aggregates. |
| doi_str_mv | 10.1039/C7NR07489A |
| format | Article |
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This work clearly brings to light that the presence of cholesterol in membranes is favorable to the interaction with Aβ peptides in oligomers or aggregates.</description><subject>Alzheimer Disease</subject><subject>Amyloid beta-Peptides - chemistry</subject><subject>Cell Membrane - chemistry</subject><subject>Cholesterol - chemistry</subject><subject>Humans</subject><subject>Peptide Fragments - chemistry</subject><subject>Protein Structure, Secondary</subject><subject>Spectrophotometry, Infrared</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1KAzEUhYMoVqsbH0CyFkbzMzNJlqX4UygK0n3Jzw2NdCYhMypd-ko-iM_k1Gq9d3HP4rvnwEHogpJrSri6mYrHZyJKqSYH6ISRkhScC3a413U5Qqdd90JIrXjNj9GIqWHLujpBH7O2h6xtH2KLo8eTr09Mi5LhBKkPDnDMuF9ByPhN56DbHr-HfoWb6GCNG2hM1i1sH13wHjIMgI1Nil34cUw5GnDYbHBofdZ50K1uY5fA9jl2NqbNGTryet3B-e8do8Xd7WL6UMyf7mfTybywSlWF8MRqWnHpS-Msq6X2jkjpKl7WDIykwxhXgTSCGUmsF8YIMEpSpQVlhI_R1c7WDrldBr9MOTQ6b5aULLc1Lv9rHODLHZxeTQNuj_71xr8BGMRwGw</recordid><startdate>20180118</startdate><enddate>20180118</enddate><creator>Henry, S</creator><creator>Bercu, N B</creator><creator>Bobo, C</creator><creator>Cullin, C</creator><creator>Molinari, M</creator><creator>Lecomte, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-9906-655X</orcidid><orcidid>https://orcid.org/0000-0003-4110-4677</orcidid><orcidid>https://orcid.org/0000-0001-8310-4849</orcidid></search><sort><creationdate>20180118</creationdate><title>Interaction of Aβ 1-42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy</title><author>Henry, S ; Bercu, N B ; Bobo, C ; Cullin, C ; Molinari, M ; Lecomte, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c995-7f0ca1538f4bdc268afd088d53462eb81111bd5e8b72b80cf7bb7eb9819a71203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alzheimer Disease</topic><topic>Amyloid beta-Peptides - chemistry</topic><topic>Cell Membrane - chemistry</topic><topic>Cholesterol - chemistry</topic><topic>Humans</topic><topic>Peptide Fragments - chemistry</topic><topic>Protein Structure, Secondary</topic><topic>Spectrophotometry, Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henry, S</creatorcontrib><creatorcontrib>Bercu, N B</creatorcontrib><creatorcontrib>Bobo, C</creatorcontrib><creatorcontrib>Cullin, C</creatorcontrib><creatorcontrib>Molinari, M</creatorcontrib><creatorcontrib>Lecomte, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henry, S</au><au>Bercu, N B</au><au>Bobo, C</au><au>Cullin, C</au><au>Molinari, M</au><au>Lecomte, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of Aβ 1-42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2018-01-18</date><risdate>2018</risdate><volume>10</volume><issue>3</issue><spage>936</spage><epage>940</epage><pages>936-940</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Toxicity of Aβ peptides involved in Alzheimer's disease is linked to the interaction of intermediate species with membranes. 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| ispartof | Nanoscale, 2018-01, Vol.10 (3), p.936-940 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1039_C7NR07489A |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Alzheimer Disease Amyloid beta-Peptides - chemistry Cell Membrane - chemistry Cholesterol - chemistry Humans Peptide Fragments - chemistry Protein Structure, Secondary Spectrophotometry, Infrared |
| title | Interaction of Aβ 1-42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy |
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