The discovery of a potent Na v 1.3 inhibitor with good oral pharmacokinetics

In this article, we describe the discovery of an aryl ether series of potent and selective Na 1.3 inhibitors. Based on structural analogy to a similar series of compounds we have previously shown bind to the domain IV voltage sensor region of Na channels, we propose this series binds in the same loc...

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Veröffentlicht in:	MedChemComm 2017-06, Vol.8 (6), p.1255-1267
Hauptverfasser:	Pryde, D C, Swain, N A, Stupple, P A, West, C W, Marron, B, Markworth, C J, Printzenhoff, D, Lin, Z, Cox, P J, Suzuki, R, McMurray, S, Waldron, G J, Payne, C E, Warmus, J S, Chapman, M L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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