Use of porous membranes in tissue barrier and co-culture models
Porous membranes enable the partitioning of cellular microenvironments in vitro , while still allowing physical and biochemical crosstalk between cells, a feature that is often necessary for recapitulating physiological functions. This article provides an overview of the different membranes used in...
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| Veröffentlicht in: | Lab on a chip 2018-06, Vol.18 (12), p.1671-1689 |
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| creator | Chung, Henry H Mireles, Marcela Kwarta, Bradley J Gaborski, Thomas R |
| description | Porous membranes enable the partitioning of cellular microenvironments
in vitro
, while still allowing physical and biochemical crosstalk between cells, a feature that is often necessary for recapitulating physiological functions. This article provides an overview of the different membranes used in tissue barrier and cellular co-culture models with a focus on experimental design and control of these systems. Specifically, we discuss how the structural, mechanical, chemical, and even the optical and transport properties of different membranes bestow specific advantages and disadvantages through the context of physiological relevance. This review also explores how membrane pore properties affect perfusion and solute permeability by developing an analytical framework to guide the design and use of tissue barrier or co-culture models. Ultimately, this review offers insight into the important aspects one must consider when using porous membranes in tissue barrier and lab-on-a-chip applications.
A tutorial review of different porous membranes utilized in tissue barrier and co-culture models with a focus on experimental design and control. |
| doi_str_mv | 10.1039/c7lc01248a |
| format | Article |
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in vitro
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A tutorial review of different porous membranes utilized in tissue barrier and co-culture models with a focus on experimental design and control.</description><subject>Animals</subject><subject>Barriers</subject><subject>Cell Line</subject><subject>Coculture Techniques</subject><subject>Crosstalk</subject><subject>Humans</subject><subject>Membranes</subject><subject>Membranes, Artificial</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Optical properties</subject><subject>Organic chemistry</subject><subject>Physiology</subject><subject>Porosity</subject><subject>Tissue Culture Techniques</subject><subject>Tissue Engineering</subject><issn>1473-0197</issn><issn>1473-0189</issn><issn>1473-0189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLHEEUhYsQUaNusk-o4CYIrfW0qjcGGeIDBtw466Iet7Wlu2tS1S347y0z46hZZHUvnI_DORyEvlJyTAmvT7zqPKFMaPsJ7VKheEWorj9v_lrtoC85PxBCpTjV22iH1VpIKuQu-rXIgGODlzHFKeMeepfsABm3Ax7bnCfAzqbUQsJ2CNjHyk_dOCXAfQzQ5X201dguw8H67qHFxe_b2VU1v7m8np3PKy85GytwjDWeOBcCBw8yhFPBqddEioaJEkwJC04QrqWnVniqgVIvpRWucToIvofOVr7LyfUQPAxjsp1Zpra36clE25qPytDem7v4aGRdK6lIMfi5NkjxzwR5NH2bPXRdaVuaG0aEYlpLxgp6-A_6EKc0lHqFklwKrYQs1NGK8inmnKDZhKHEvOxiZmo--7vLeYG_v4-_QV-HKMC3FZCy36hvwxb9x_90swwNfwY2453h</recordid><startdate>20180612</startdate><enddate>20180612</enddate><creator>Chung, Henry H</creator><creator>Mireles, Marcela</creator><creator>Kwarta, Bradley J</creator><creator>Gaborski, Thomas R</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3972-5570</orcidid><orcidid>https://orcid.org/0000-0002-3676-3208</orcidid><orcidid>https://orcid.org/0000-0002-7783-7306</orcidid></search><sort><creationdate>20180612</creationdate><title>Use of porous membranes in tissue barrier and co-culture models</title><author>Chung, Henry H ; Mireles, Marcela ; Kwarta, Bradley J ; Gaborski, Thomas R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-eb22fc0bbdd3ece5dd6431c8054f2400174aeb40385c1a4c18e11c55a4bfb8d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Barriers</topic><topic>Cell Line</topic><topic>Coculture Techniques</topic><topic>Crosstalk</topic><topic>Humans</topic><topic>Membranes</topic><topic>Membranes, Artificial</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Optical properties</topic><topic>Organic chemistry</topic><topic>Physiology</topic><topic>Porosity</topic><topic>Tissue Culture Techniques</topic><topic>Tissue Engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Henry H</creatorcontrib><creatorcontrib>Mireles, Marcela</creatorcontrib><creatorcontrib>Kwarta, Bradley J</creatorcontrib><creatorcontrib>Gaborski, Thomas R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lab on a chip</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Henry H</au><au>Mireles, Marcela</au><au>Kwarta, Bradley J</au><au>Gaborski, Thomas R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of porous membranes in tissue barrier and co-culture models</atitle><jtitle>Lab on a chip</jtitle><addtitle>Lab Chip</addtitle><date>2018-06-12</date><risdate>2018</risdate><volume>18</volume><issue>12</issue><spage>1671</spage><epage>1689</epage><pages>1671-1689</pages><issn>1473-0197</issn><issn>1473-0189</issn><eissn>1473-0189</eissn><abstract>Porous membranes enable the partitioning of cellular microenvironments
in vitro
, while still allowing physical and biochemical crosstalk between cells, a feature that is often necessary for recapitulating physiological functions. This article provides an overview of the different membranes used in tissue barrier and cellular co-culture models with a focus on experimental design and control of these systems. Specifically, we discuss how the structural, mechanical, chemical, and even the optical and transport properties of different membranes bestow specific advantages and disadvantages through the context of physiological relevance. This review also explores how membrane pore properties affect perfusion and solute permeability by developing an analytical framework to guide the design and use of tissue barrier or co-culture models. Ultimately, this review offers insight into the important aspects one must consider when using porous membranes in tissue barrier and lab-on-a-chip applications.
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| fulltext | fulltext |
| identifier | ISSN: 1473-0197 |
| ispartof | Lab on a chip, 2018-06, Vol.18 (12), p.1671-1689 |
| issn | 1473-0197 1473-0189 1473-0189 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Barriers Cell Line Coculture Techniques Crosstalk Humans Membranes Membranes, Artificial Mice Models, Biological Optical properties Organic chemistry Physiology Porosity Tissue Culture Techniques Tissue Engineering |
| title | Use of porous membranes in tissue barrier and co-culture models |
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