The synthesis of LA-Fe 3 O 4 @PDA-PEG-DOX for photothermal therapy-chemotherapy
A facile methodology is presented to construct a multifunctional nanocomposite that integrates photothermal therapy and specific drug release into a single nanostructure. Firstly, magnetic Fe O @polydopamine core-shell nanoparticles (Fe O @PDA) were synthesized via a reversed-phase microemulsion app...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2018-02, Vol.47 (7), p.2435-2443 |
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| container_title | Dalton transactions : an international journal of inorganic chemistry |
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| creator | Chen, Yuhua Zhang, Feng Wang, Qian Lin, Huiming Tong, Ruihan An, Na Qu, Fengyu |
| description | A facile methodology is presented to construct a multifunctional nanocomposite that integrates photothermal therapy and specific drug release into a single nanostructure. Firstly, magnetic Fe
O
@polydopamine core-shell nanoparticles (Fe
O
@PDA) were synthesized via a reversed-phase microemulsion approach. By varying the amount of DA, Fe
O
@PDA with a particle size of 28-38 nm can be obtained. To further ensure the monodispersity, biocompatibility and specific uptake, PEG and lactobionic acid (LA) were grafted onto Fe
O
@PDA (LA-Fe
O
@PDA-PEG), whose fast photothermal conversion is derived by the combination of Fe
O
and PDA with high near infrared (NIR) absorption. Then, doxorubicin hydrochloride (DOX) was adopted as the typical anticancer drug, which was loaded onto LA-Fe
O
@PDA-PEG via electrostatic and π-π stacking interaction. The release kinetics investigation further demonstrated the acid/heat-triggered DOX release. HepG2 cells (hepatocellular cell line) were used as the target cancer cells, and the fast uptake was due to the nanoparticle size and abundant asialoglycoprotein receptors on HepG2 cells. Besides, an external magnetic field also can improve the uptake, especially when the magnet is placed at the bottom of the cell disk. The enhanced specific cytotoxicity toward HepG2 cells was also ascribed to the synergistic effect of chemo- and photothermal therapy. Based on the novel properties, the LA-Fe
O
@PDA-PEG-DOX nanocomposite showed its potential application in hepatocyte therapy. |
| doi_str_mv | 10.1039/c7dt04080f |
| format | Article |
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O
@polydopamine core-shell nanoparticles (Fe
O
@PDA) were synthesized via a reversed-phase microemulsion approach. By varying the amount of DA, Fe
O
@PDA with a particle size of 28-38 nm can be obtained. To further ensure the monodispersity, biocompatibility and specific uptake, PEG and lactobionic acid (LA) were grafted onto Fe
O
@PDA (LA-Fe
O
@PDA-PEG), whose fast photothermal conversion is derived by the combination of Fe
O
and PDA with high near infrared (NIR) absorption. Then, doxorubicin hydrochloride (DOX) was adopted as the typical anticancer drug, which was loaded onto LA-Fe
O
@PDA-PEG via electrostatic and π-π stacking interaction. The release kinetics investigation further demonstrated the acid/heat-triggered DOX release. HepG2 cells (hepatocellular cell line) were used as the target cancer cells, and the fast uptake was due to the nanoparticle size and abundant asialoglycoprotein receptors on HepG2 cells. Besides, an external magnetic field also can improve the uptake, especially when the magnet is placed at the bottom of the cell disk. The enhanced specific cytotoxicity toward HepG2 cells was also ascribed to the synergistic effect of chemo- and photothermal therapy. Based on the novel properties, the LA-Fe
O
@PDA-PEG-DOX nanocomposite showed its potential application in hepatocyte therapy.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/c7dt04080f</identifier><identifier>PMID: 29379913</identifier><language>eng</language><publisher>England</publisher><subject>Biological Transport ; Chemistry Techniques, Synthetic ; Disaccharides - chemistry ; Doxorubicin - chemistry ; Doxorubicin - therapeutic use ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; Drug Carriers - metabolism ; Drug Liberation ; Hep G2 Cells ; Humans ; Indoles - chemistry ; Magnetite Nanoparticles - chemistry ; Particle Size ; Phototherapy - methods ; Polyethylene Glycols - chemistry ; Polymers - chemistry</subject><ispartof>Dalton transactions : an international journal of inorganic chemistry, 2018-02, Vol.47 (7), p.2435-2443</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c993-d4c32ee50ece0add51d96395cf7f3eaf42d91569449b83a26eae535a5dfb07b3</citedby><cites>FETCH-LOGICAL-c993-d4c32ee50ece0add51d96395cf7f3eaf42d91569449b83a26eae535a5dfb07b3</cites><orcidid>0000-0002-6426-5812 ; 0000-0003-3902-6286</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27913,27914</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29379913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yuhua</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Lin, Huiming</creatorcontrib><creatorcontrib>Tong, Ruihan</creatorcontrib><creatorcontrib>An, Na</creatorcontrib><creatorcontrib>Qu, Fengyu</creatorcontrib><title>The synthesis of LA-Fe 3 O 4 @PDA-PEG-DOX for photothermal therapy-chemotherapy</title><title>Dalton transactions : an international journal of inorganic chemistry</title><addtitle>Dalton Trans</addtitle><description>A facile methodology is presented to construct a multifunctional nanocomposite that integrates photothermal therapy and specific drug release into a single nanostructure. Firstly, magnetic Fe
O
@polydopamine core-shell nanoparticles (Fe
O
@PDA) were synthesized via a reversed-phase microemulsion approach. By varying the amount of DA, Fe
O
@PDA with a particle size of 28-38 nm can be obtained. To further ensure the monodispersity, biocompatibility and specific uptake, PEG and lactobionic acid (LA) were grafted onto Fe
O
@PDA (LA-Fe
O
@PDA-PEG), whose fast photothermal conversion is derived by the combination of Fe
O
and PDA with high near infrared (NIR) absorption. Then, doxorubicin hydrochloride (DOX) was adopted as the typical anticancer drug, which was loaded onto LA-Fe
O
@PDA-PEG via electrostatic and π-π stacking interaction. The release kinetics investigation further demonstrated the acid/heat-triggered DOX release. HepG2 cells (hepatocellular cell line) were used as the target cancer cells, and the fast uptake was due to the nanoparticle size and abundant asialoglycoprotein receptors on HepG2 cells. Besides, an external magnetic field also can improve the uptake, especially when the magnet is placed at the bottom of the cell disk. The enhanced specific cytotoxicity toward HepG2 cells was also ascribed to the synergistic effect of chemo- and photothermal therapy. Based on the novel properties, the LA-Fe
O
@PDA-PEG-DOX nanocomposite showed its potential application in hepatocyte therapy.</description><subject>Biological Transport</subject><subject>Chemistry Techniques, Synthetic</subject><subject>Disaccharides - chemistry</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - therapeutic use</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - metabolism</subject><subject>Drug Liberation</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Indoles - chemistry</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Particle Size</subject><subject>Phototherapy - methods</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymers - chemistry</subject><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEURYMotlY3_gDJWogmecmk2Vn6pVCYgl24GzLJC1PpOMOkLvrv29ra1b0XDndxCHkU_EVwsK_ehC1XfMjjFekLZQyzEtT1pcusR-5S-uZcSq7lLelJC8ZaAX2SryqkafezrTCtE20iXYzYDCnQnCr6tpyM2HI6Z5P8i8amo23VbJsD29VuQ4_p2h3zFdbNedyTm-g2CR_OOSCfs-lq_M4W-fxjPFowby2woDxIRM3RI3chaBFsBlb7aCKgi0oGK3RmlbLlEJzM0KEG7XSIJTclDMjz6dV3TUodxqLt1rXrdoXgxdFJMTaT1Z-T2QF-OsHtb1ljuKD_EmAPjDdbGQ</recordid><startdate>20180213</startdate><enddate>20180213</enddate><creator>Chen, Yuhua</creator><creator>Zhang, Feng</creator><creator>Wang, Qian</creator><creator>Lin, Huiming</creator><creator>Tong, Ruihan</creator><creator>An, Na</creator><creator>Qu, Fengyu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-6426-5812</orcidid><orcidid>https://orcid.org/0000-0003-3902-6286</orcidid></search><sort><creationdate>20180213</creationdate><title>The synthesis of LA-Fe 3 O 4 @PDA-PEG-DOX for photothermal therapy-chemotherapy</title><author>Chen, Yuhua ; Zhang, Feng ; Wang, Qian ; Lin, Huiming ; Tong, Ruihan ; An, Na ; Qu, Fengyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c993-d4c32ee50ece0add51d96395cf7f3eaf42d91569449b83a26eae535a5dfb07b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biological Transport</topic><topic>Chemistry Techniques, Synthetic</topic><topic>Disaccharides - chemistry</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - therapeutic use</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - metabolism</topic><topic>Drug Liberation</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Indoles - chemistry</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Particle Size</topic><topic>Phototherapy - methods</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymers - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yuhua</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Lin, Huiming</creatorcontrib><creatorcontrib>Tong, Ruihan</creatorcontrib><creatorcontrib>An, Na</creatorcontrib><creatorcontrib>Qu, Fengyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yuhua</au><au>Zhang, Feng</au><au>Wang, Qian</au><au>Lin, Huiming</au><au>Tong, Ruihan</au><au>An, Na</au><au>Qu, Fengyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The synthesis of LA-Fe 3 O 4 @PDA-PEG-DOX for photothermal therapy-chemotherapy</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><addtitle>Dalton Trans</addtitle><date>2018-02-13</date><risdate>2018</risdate><volume>47</volume><issue>7</issue><spage>2435</spage><epage>2443</epage><pages>2435-2443</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>A facile methodology is presented to construct a multifunctional nanocomposite that integrates photothermal therapy and specific drug release into a single nanostructure. Firstly, magnetic Fe
O
@polydopamine core-shell nanoparticles (Fe
O
@PDA) were synthesized via a reversed-phase microemulsion approach. By varying the amount of DA, Fe
O
@PDA with a particle size of 28-38 nm can be obtained. To further ensure the monodispersity, biocompatibility and specific uptake, PEG and lactobionic acid (LA) were grafted onto Fe
O
@PDA (LA-Fe
O
@PDA-PEG), whose fast photothermal conversion is derived by the combination of Fe
O
and PDA with high near infrared (NIR) absorption. Then, doxorubicin hydrochloride (DOX) was adopted as the typical anticancer drug, which was loaded onto LA-Fe
O
@PDA-PEG via electrostatic and π-π stacking interaction. The release kinetics investigation further demonstrated the acid/heat-triggered DOX release. HepG2 cells (hepatocellular cell line) were used as the target cancer cells, and the fast uptake was due to the nanoparticle size and abundant asialoglycoprotein receptors on HepG2 cells. Besides, an external magnetic field also can improve the uptake, especially when the magnet is placed at the bottom of the cell disk. The enhanced specific cytotoxicity toward HepG2 cells was also ascribed to the synergistic effect of chemo- and photothermal therapy. Based on the novel properties, the LA-Fe
O
@PDA-PEG-DOX nanocomposite showed its potential application in hepatocyte therapy.</abstract><cop>England</cop><pmid>29379913</pmid><doi>10.1039/c7dt04080f</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6426-5812</orcidid><orcidid>https://orcid.org/0000-0003-3902-6286</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2018-02, Vol.47 (7), p.2435-2443 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biological Transport Chemistry Techniques, Synthetic Disaccharides - chemistry Doxorubicin - chemistry Doxorubicin - therapeutic use Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - metabolism Drug Liberation Hep G2 Cells Humans Indoles - chemistry Magnetite Nanoparticles - chemistry Particle Size Phototherapy - methods Polyethylene Glycols - chemistry Polymers - chemistry |
| title | The synthesis of LA-Fe 3 O 4 @PDA-PEG-DOX for photothermal therapy-chemotherapy |
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