A lysosome-targeting colorimetric and fluorescent dual signal probe for sensitive detection and bioimaging of hydrogen sulfide
In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4 H -chromen-4-one ( DMC ), for the detection of hydrogen sulfide (H 2 S) based on excited-state intramolecular proton transfer (ESIPT). Upon the treatment with H 2 S, a significant enha...
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| Veröffentlicht in: | Analytical methods 2018-01, Vol.1 (6), p.64-61 |
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| creator | Wu, Cuiyan Hu, Xiaojun Gu, Biao Yin, Peng Su, Wei Li, Yaqian Lu, Qiujun Zhang, Youyu Li, Haitao |
| description | In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4
H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT). Upon the treatment with H
2
S, a significant enhancement in the fluorescence was observed along with a distinct color change from yellow to colorless. This probe shows a low background spectroscopic signal, large Stokes shift, good sensitivity, and high selectivity towards H
2
S. Most importantly,
DMC
has low toxicity and excellent cell permeability, and could be applied to visualizing H
2
S in lysosomes.
In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4
H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT). |
| doi_str_mv | 10.1039/c7ay02492d |
| format | Article |
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H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT). Upon the treatment with H
2
S, a significant enhancement in the fluorescence was observed along with a distinct color change from yellow to colorless. This probe shows a low background spectroscopic signal, large Stokes shift, good sensitivity, and high selectivity towards H
2
S. Most importantly,
DMC
has low toxicity and excellent cell permeability, and could be applied to visualizing H
2
S in lysosomes.
In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4
H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT).</description><identifier>ISSN: 1759-9660</identifier><identifier>EISSN: 1759-9679</identifier><identifier>DOI: 10.1039/c7ay02492d</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Cell permeability ; Colorimetry ; Fluorescence ; Hydrogen sulfide ; Lysosomes ; Medical imaging ; Sulfide ; Toxicity</subject><ispartof>Analytical methods, 2018-01, Vol.1 (6), p.64-61</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c318t-3dd97c80f11c0a962d9580cd7471df9085fa9ebf424a464c7dacc7a5e9f0786d3</citedby><cites>FETCH-LOGICAL-c318t-3dd97c80f11c0a962d9580cd7471df9085fa9ebf424a464c7dacc7a5e9f0786d3</cites><orcidid>0000-0001-9160-8334</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Wu, Cuiyan</creatorcontrib><creatorcontrib>Hu, Xiaojun</creatorcontrib><creatorcontrib>Gu, Biao</creatorcontrib><creatorcontrib>Yin, Peng</creatorcontrib><creatorcontrib>Su, Wei</creatorcontrib><creatorcontrib>Li, Yaqian</creatorcontrib><creatorcontrib>Lu, Qiujun</creatorcontrib><creatorcontrib>Zhang, Youyu</creatorcontrib><creatorcontrib>Li, Haitao</creatorcontrib><title>A lysosome-targeting colorimetric and fluorescent dual signal probe for sensitive detection and bioimaging of hydrogen sulfide</title><title>Analytical methods</title><description>In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4
H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT). Upon the treatment with H
2
S, a significant enhancement in the fluorescence was observed along with a distinct color change from yellow to colorless. This probe shows a low background spectroscopic signal, large Stokes shift, good sensitivity, and high selectivity towards H
2
S. Most importantly,
DMC
has low toxicity and excellent cell permeability, and could be applied to visualizing H
2
S in lysosomes.
In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4
H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT).</description><subject>Cell permeability</subject><subject>Colorimetry</subject><subject>Fluorescence</subject><subject>Hydrogen sulfide</subject><subject>Lysosomes</subject><subject>Medical imaging</subject><subject>Sulfide</subject><subject>Toxicity</subject><issn>1759-9660</issn><issn>1759-9679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LAzEQhoMoWKsX70LAm7Ca7EeyOZb6CQUvevC0pMlkTdluapIV9uJvN22lnt45PPMy8yB0ScktJYW4U1yOJC9Fro_QhPJKZIJxcXyYGTlFZyGsCGGiYHSCfma4G4MLbg1ZlL6FaPsWK9c5b9cQvVVY9hqbbnAegoI-Yj3IDgfb9ik23i0BG-dxgD7YaL8Ba4igonX9bnNpnV3LdtvqDP4ctXct9DgMnbEaztGJkV2Ai7-covfHh7f5c7Z4fXqZzxaZKmgds0JrwVVNDKWKSMFyLaqaKM1LTrURpK6MFLA0ZV7KkpWKa6mSigqEIbxmupii631vOvhrgBCblRt8-iA0OSGC0aquaKJu9pTyLgQPptkkC9KPDSXN1m8z57OPnd_7BF_tYR_Ugfv3X_wCMBx6rQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Wu, Cuiyan</creator><creator>Hu, Xiaojun</creator><creator>Gu, Biao</creator><creator>Yin, Peng</creator><creator>Su, Wei</creator><creator>Li, Yaqian</creator><creator>Lu, Qiujun</creator><creator>Zhang, Youyu</creator><creator>Li, Haitao</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-9160-8334</orcidid></search><sort><creationdate>20180101</creationdate><title>A lysosome-targeting colorimetric and fluorescent dual signal probe for sensitive detection and bioimaging of hydrogen sulfide</title><author>Wu, Cuiyan ; Hu, Xiaojun ; Gu, Biao ; Yin, Peng ; Su, Wei ; Li, Yaqian ; Lu, Qiujun ; Zhang, Youyu ; Li, Haitao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-3dd97c80f11c0a962d9580cd7471df9085fa9ebf424a464c7dacc7a5e9f0786d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cell permeability</topic><topic>Colorimetry</topic><topic>Fluorescence</topic><topic>Hydrogen sulfide</topic><topic>Lysosomes</topic><topic>Medical imaging</topic><topic>Sulfide</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Cuiyan</creatorcontrib><creatorcontrib>Hu, Xiaojun</creatorcontrib><creatorcontrib>Gu, Biao</creatorcontrib><creatorcontrib>Yin, Peng</creatorcontrib><creatorcontrib>Su, Wei</creatorcontrib><creatorcontrib>Li, Yaqian</creatorcontrib><creatorcontrib>Lu, Qiujun</creatorcontrib><creatorcontrib>Zhang, Youyu</creatorcontrib><creatorcontrib>Li, Haitao</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Cuiyan</au><au>Hu, Xiaojun</au><au>Gu, Biao</au><au>Yin, Peng</au><au>Su, Wei</au><au>Li, Yaqian</au><au>Lu, Qiujun</au><au>Zhang, Youyu</au><au>Li, Haitao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A lysosome-targeting colorimetric and fluorescent dual signal probe for sensitive detection and bioimaging of hydrogen sulfide</atitle><jtitle>Analytical methods</jtitle><date>2018-01-01</date><risdate>2018</risdate><volume>1</volume><issue>6</issue><spage>64</spage><epage>61</epage><pages>64-61</pages><issn>1759-9660</issn><eissn>1759-9679</eissn><abstract>In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4
H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT). Upon the treatment with H
2
S, a significant enhancement in the fluorescence was observed along with a distinct color change from yellow to colorless. This probe shows a low background spectroscopic signal, large Stokes shift, good sensitivity, and high selectivity towards H
2
S. Most importantly,
DMC
has low toxicity and excellent cell permeability, and could be applied to visualizing H
2
S in lysosomes.
In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4
H
-chromen-4-one (
DMC
), for the detection of hydrogen sulfide (H
2
S) based on excited-state intramolecular proton transfer (ESIPT).</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/c7ay02492d</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9160-8334</orcidid></addata></record> |
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| identifier | ISSN: 1759-9660 |
| ispartof | Analytical methods, 2018-01, Vol.1 (6), p.64-61 |
| issn | 1759-9660 1759-9679 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C7AY02492D |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Cell permeability Colorimetry Fluorescence Hydrogen sulfide Lysosomes Medical imaging Sulfide Toxicity |
| title | A lysosome-targeting colorimetric and fluorescent dual signal probe for sensitive detection and bioimaging of hydrogen sulfide |
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