A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets

A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets

We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a...

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Veröffentlicht in:Nanoscale 2016-11, Vol.8 (43), p.18291-18295
Hauptverfasser: Dai, Ziwen, Gao, Qi, Cheung, Man Ching, Leung, Hoi Man, Lau, Terrence Chi Kong, Sleiman, Hanadi F, Lai, King Wai Chiu, Lo, Pik Kwan
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Sprache:eng
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DNA - chemistry
Nanotubes
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container_end_page 18295
container_issue 43
container_start_page 18291
container_title Nanoscale
container_volume 8
creator Dai, Ziwen
Gao, Qi
Cheung, Man Ching
Leung, Hoi Man
Lau, Terrence Chi Kong
Sleiman, Hanadi F
Lai, King Wai Chiu
Lo, Pik Kwan
description We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a framework for spatial orientation and positioning of different aptamer-binding ligands in a 'pea-pod' architecture.
doi_str_mv 10.1039/c6nr05411k
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subjects DNA - chemistry
Nanotubes
title A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets
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