Tricarbonylrhenium() complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer
Complexes [ReCl(CO) 3 (H2AcPh)] ( 1 ), [ReCl(CO) 3 (H2Ac p ClPh)]0.5C 7 H 8 ( 2 ) and [ReCl(CO) 3 (H2Ac p NO 2 Ph)]0.5C 7 H 8 ( 3 ) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its para -chlorophenylhydrazone (H2Ac p ClPh) and para -nitrophenylhydrazone (H2Ac p NO 2 Ph) analogues...
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| Veröffentlicht in: | New journal of chemistry 2016-01, Vol.4 (9), p.7379-7387 |
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| container_issue | 9 |
| container_start_page | 7379 |
| container_title | New journal of chemistry |
| container_volume | 4 |
| creator | Garcia, Camila Vargas Parrilha, Gabrieli Lessa Rodrigues, Bernardo Lages Teixeira, Sarah Fernandes de Azevedo, Ricardo Alexandre Ferreira, Adilson Kleber Beraldo, Heloisa |
| description | Complexes [ReCl(CO)
3
(H2AcPh)] (
1
), [ReCl(CO)
3
(H2Ac
p
ClPh)]0.5C
7
H
8
(
2
) and [ReCl(CO)
3
(H2Ac
p
NO
2
Ph)]0.5C
7
H
8
(
3
) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its
para
-chlorophenylhydrazone (H2Ac
p
ClPh) and
para
-nitrophenylhydrazone (H2Ac
p
NO
2
Ph) analogues. Coordination to tricarbonylrhenium(
i
) resulted in a higher antiproliferative activity against NCI-H460 human large cell lung cancer. Complexes (
2
) and (
3
) induced apoptosis on NCI-H460 cells. Complex (
2
) induced mitochondrial damage while treatment with
3
showed a later response, suggesting that probably the same effect would be observed at higher concentrations or longer treatments. Both complexes (
2
) and (
3
) showed a high antioxidant activity,
2
being more potent in reducing intracellular reactive oxygen species (ROS) production.
Tricarbonylrhenium(
i
)-hydrazone complexes showed antiproliferative activity against NCI-H460 cells. The mode of action involves apoptosis and ROS scavenge. |
| doi_str_mv | 10.1039/c6nj00050a |
| format | Article |
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3
(H2AcPh)] (
1
), [ReCl(CO)
3
(H2Ac
p
ClPh)]0.5C
7
H
8
(
2
) and [ReCl(CO)
3
(H2Ac
p
NO
2
Ph)]0.5C
7
H
8
(
3
) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its
para
-chlorophenylhydrazone (H2Ac
p
ClPh) and
para
-nitrophenylhydrazone (H2Ac
p
NO
2
Ph) analogues. Coordination to tricarbonylrhenium(
i
) resulted in a higher antiproliferative activity against NCI-H460 human large cell lung cancer. Complexes (
2
) and (
3
) induced apoptosis on NCI-H460 cells. Complex (
2
) induced mitochondrial damage while treatment with
3
showed a later response, suggesting that probably the same effect would be observed at higher concentrations or longer treatments. Both complexes (
2
) and (
3
) showed a high antioxidant activity,
2
being more potent in reducing intracellular reactive oxygen species (ROS) production.
Tricarbonylrhenium(
i
)-hydrazone complexes showed antiproliferative activity against NCI-H460 cells. The mode of action involves apoptosis and ROS scavenge.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/c6nj00050a</identifier><language>eng</language><ispartof>New journal of chemistry, 2016-01, Vol.4 (9), p.7379-7387</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-87ae7c78eedee365274f722c277711187dbf1888a0f3fb3ab900738d942c6e4c3</citedby><cites>FETCH-LOGICAL-c253t-87ae7c78eedee365274f722c277711187dbf1888a0f3fb3ab900738d942c6e4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Garcia, Camila Vargas</creatorcontrib><creatorcontrib>Parrilha, Gabrieli Lessa</creatorcontrib><creatorcontrib>Rodrigues, Bernardo Lages</creatorcontrib><creatorcontrib>Teixeira, Sarah Fernandes</creatorcontrib><creatorcontrib>de Azevedo, Ricardo Alexandre</creatorcontrib><creatorcontrib>Ferreira, Adilson Kleber</creatorcontrib><creatorcontrib>Beraldo, Heloisa</creatorcontrib><title>Tricarbonylrhenium() complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer</title><title>New journal of chemistry</title><description>Complexes [ReCl(CO)
3
(H2AcPh)] (
1
), [ReCl(CO)
3
(H2Ac
p
ClPh)]0.5C
7
H
8
(
2
) and [ReCl(CO)
3
(H2Ac
p
NO
2
Ph)]0.5C
7
H
8
(
3
) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its
para
-chlorophenylhydrazone (H2Ac
p
ClPh) and
para
-nitrophenylhydrazone (H2Ac
p
NO
2
Ph) analogues. Coordination to tricarbonylrhenium(
i
) resulted in a higher antiproliferative activity against NCI-H460 human large cell lung cancer. Complexes (
2
) and (
3
) induced apoptosis on NCI-H460 cells. Complex (
2
) induced mitochondrial damage while treatment with
3
showed a later response, suggesting that probably the same effect would be observed at higher concentrations or longer treatments. Both complexes (
2
) and (
3
) showed a high antioxidant activity,
2
being more potent in reducing intracellular reactive oxygen species (ROS) production.
Tricarbonylrhenium(
i
)-hydrazone complexes showed antiproliferative activity against NCI-H460 cells. The mode of action involves apoptosis and ROS scavenge.</description><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpF0D1PwzAUhWELgUQpLOxIHgHJ4I_ETsYqAlqEylLmyHFuGiPHqZwUGgZ-O4EimO4dHp3hReic0RtGRXprpH-llMZUH6AJEzIlKZfscPxZFBEaR_IYnXTdaBhTkk3Q5ypYo0PR-sGFGrzdNpdX2LTNxsEOOvxu-xpzog30g9sMwZbWAykh2DcocT2UQX-0foQ6ADZD3_btzhrct3iZLcg8khTX20Z77HRYjwKcw27r19hobyCcoqNKuw7Ofu8UvdzfrbI5eXp-WGSzJ2J4LHqSKA3KqASgBBAy5iqqFOeGK6UYY4kqi4olSaJpJapC6CKlVImkTCNuJERGTNH1fteEtusCVPkm2EaHIWc0_y6XZ3L5-FNuNuKLPQ6d-XP_ZcUX-lxsfQ</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Garcia, Camila Vargas</creator><creator>Parrilha, Gabrieli Lessa</creator><creator>Rodrigues, Bernardo Lages</creator><creator>Teixeira, Sarah Fernandes</creator><creator>de Azevedo, Ricardo Alexandre</creator><creator>Ferreira, Adilson Kleber</creator><creator>Beraldo, Heloisa</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20160101</creationdate><title>Tricarbonylrhenium() complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer</title><author>Garcia, Camila Vargas ; Parrilha, Gabrieli Lessa ; Rodrigues, Bernardo Lages ; Teixeira, Sarah Fernandes ; de Azevedo, Ricardo Alexandre ; Ferreira, Adilson Kleber ; Beraldo, Heloisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-87ae7c78eedee365274f722c277711187dbf1888a0f3fb3ab900738d942c6e4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia, Camila Vargas</creatorcontrib><creatorcontrib>Parrilha, Gabrieli Lessa</creatorcontrib><creatorcontrib>Rodrigues, Bernardo Lages</creatorcontrib><creatorcontrib>Teixeira, Sarah Fernandes</creatorcontrib><creatorcontrib>de Azevedo, Ricardo Alexandre</creatorcontrib><creatorcontrib>Ferreira, Adilson Kleber</creatorcontrib><creatorcontrib>Beraldo, Heloisa</creatorcontrib><collection>CrossRef</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, Camila Vargas</au><au>Parrilha, Gabrieli Lessa</au><au>Rodrigues, Bernardo Lages</au><au>Teixeira, Sarah Fernandes</au><au>de Azevedo, Ricardo Alexandre</au><au>Ferreira, Adilson Kleber</au><au>Beraldo, Heloisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tricarbonylrhenium() complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer</atitle><jtitle>New journal of chemistry</jtitle><date>2016-01-01</date><risdate>2016</risdate><volume>4</volume><issue>9</issue><spage>7379</spage><epage>7387</epage><pages>7379-7387</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>Complexes [ReCl(CO)
3
(H2AcPh)] (
1
), [ReCl(CO)
3
(H2Ac
p
ClPh)]0.5C
7
H
8
(
2
) and [ReCl(CO)
3
(H2Ac
p
NO
2
Ph)]0.5C
7
H
8
(
3
) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh) and its
para
-chlorophenylhydrazone (H2Ac
p
ClPh) and
para
-nitrophenylhydrazone (H2Ac
p
NO
2
Ph) analogues. Coordination to tricarbonylrhenium(
i
) resulted in a higher antiproliferative activity against NCI-H460 human large cell lung cancer. Complexes (
2
) and (
3
) induced apoptosis on NCI-H460 cells. Complex (
2
) induced mitochondrial damage while treatment with
3
showed a later response, suggesting that probably the same effect would be observed at higher concentrations or longer treatments. Both complexes (
2
) and (
3
) showed a high antioxidant activity,
2
being more potent in reducing intracellular reactive oxygen species (ROS) production.
Tricarbonylrhenium(
i
)-hydrazone complexes showed antiproliferative activity against NCI-H460 cells. The mode of action involves apoptosis and ROS scavenge.</abstract><doi>10.1039/c6nj00050a</doi><tpages>9</tpages></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Tricarbonylrhenium() complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer |
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