Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles

Quinonoid compounds based on 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles were synthesized using simple methodologies and evaluated against T. cruzi , the etiological agent of Chagas disease, and cancer cell lines PC3, HCT-116, HL-60, MDA-MB-435 and SF-295. The cytotoxic pot...

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Veröffentlicht in:	MedChemComm 2016-08, Vol.7 (8), p.1555-1563
Hauptverfasser:	Bahia, Samara Ben B. B, Reis, Wallace J, Jardim, Guilherme A. M, Souto, Francielly T, de Simone, Carlos A, Gatto, Claudia C, Menna-Barreto, Rubem F. S, de Castro, Solange L, Cavalcanti, Bruno C, Pessoa, Claudia, Araujo, Maria H, da Silva Júnior, Eufrânio N
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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