Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices

Therapeutic strategies have been reported that depend on synthetic network devices in which a urate-sensing transcriptional regulator detects pathological levels of urate and triggers production or release of urate oxidase. The transcription factor involved, HucR, is a member of the multiple antibio...

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Veröffentlicht in:	Molecular bioSystems 2016-07, Vol.12 (8), p.2417-2426
Hauptverfasser:	Deochand, D. K, Perera, I. C, Crochet, R. B, Gilbert, N. C, Newcomer, M. E, Grove, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites DNA - chemistry DNA - genetics DNA - metabolism Histidine - metabolism Hydrogen-Ion Concentration Ligands Models, Molecular Molecular Conformation Protein Binding Protein Folding Thermodynamics Transcription Factors - chemistry Transcription Factors - metabolism
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