Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis o...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2017, Vol.19 (4), p.905-909
Hauptverfasser: Hock, Katharina J., Mertens, Lucas, Metze, Friederike K., Schmittmann, Clemens, Koenigs, Rene M.
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container_title Green chemistry : an international journal and green chemistry resource : GC
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creator Hock, Katharina J.
Mertens, Lucas
Metze, Friederike K.
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Koenigs, Rene M.
description Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.
doi_str_mv 10.1039/C6GC03187K
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title Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions
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