Osmo-solidification of all-aqueous emulsion with enhanced preservation of protein activity
The encapsulation of bio-active ingredients, such as proteins, in solidified particles via emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of non-aqueous solvents and unfavorable conditions during the solidification process. Herein, we introduce an &quo...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-02, Vol.4 (7), p.1213-1218 |
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| container_issue | 7 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
| container_volume | 4 |
| creator | Ma, Qingming Song, Yang Baier, Grit Holtze, Christian Shum, Ho Cheung |
| description | The encapsulation of bio-active ingredients, such as proteins, in solidified particles
via
emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of non-aqueous solvents and unfavorable conditions during the solidification process. Herein, we introduce an "osmo-solidification" approach that solidifies all-aqueous emulsion droplets by the osmotic extraction of water for encapsulating proteins and demonstrate the superior preservation of their activity. The osmo-solidification approach combines the solidification of droplets to particles and protein encapsulation in one step. Proteins encapsulated preserve their activity after osmo-solidification better than conventional solidification approaches. To the best of our knowledge, this is the first time that the osmo-solidification of all-aqueous emulsion is introduced in the fabrication of emulsion-based particles and that the stability of encapsulated proteins can be enhanced to an unprecedentedly high level.
An "osmo-solidification" approach that solidifies all-aqueous emulsion droplets for encapsulating proteins with superior preservation of their activity. |
| doi_str_mv | 10.1039/c5tb02187a |
| format | Article |
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via
emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of non-aqueous solvents and unfavorable conditions during the solidification process. Herein, we introduce an "osmo-solidification" approach that solidifies all-aqueous emulsion droplets by the osmotic extraction of water for encapsulating proteins and demonstrate the superior preservation of their activity. The osmo-solidification approach combines the solidification of droplets to particles and protein encapsulation in one step. Proteins encapsulated preserve their activity after osmo-solidification better than conventional solidification approaches. To the best of our knowledge, this is the first time that the osmo-solidification of all-aqueous emulsion is introduced in the fabrication of emulsion-based particles and that the stability of encapsulated proteins can be enhanced to an unprecedentedly high level.
An "osmo-solidification" approach that solidifies all-aqueous emulsion droplets for encapsulating proteins with superior preservation of their activity.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c5tb02187a</identifier><identifier>PMID: 32262976</identifier><language>eng</language><publisher>England</publisher><subject>Biochemistry ; Biology ; Droplets ; Emulsions ; Encapsulation ; Preservation ; Proteins ; Solidification</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2016-02, Vol.4 (7), p.1213-1218</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-e22990692356bf148e7f1c149c37386660508ee3cb44eddd953927fc9a72722c3</citedby><cites>FETCH-LOGICAL-c342t-e22990692356bf148e7f1c149c37386660508ee3cb44eddd953927fc9a72722c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32262976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Qingming</creatorcontrib><creatorcontrib>Song, Yang</creatorcontrib><creatorcontrib>Baier, Grit</creatorcontrib><creatorcontrib>Holtze, Christian</creatorcontrib><creatorcontrib>Shum, Ho Cheung</creatorcontrib><title>Osmo-solidification of all-aqueous emulsion with enhanced preservation of protein activity</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>The encapsulation of bio-active ingredients, such as proteins, in solidified particles
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emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of non-aqueous solvents and unfavorable conditions during the solidification process. Herein, we introduce an "osmo-solidification" approach that solidifies all-aqueous emulsion droplets by the osmotic extraction of water for encapsulating proteins and demonstrate the superior preservation of their activity. The osmo-solidification approach combines the solidification of droplets to particles and protein encapsulation in one step. Proteins encapsulated preserve their activity after osmo-solidification better than conventional solidification approaches. To the best of our knowledge, this is the first time that the osmo-solidification of all-aqueous emulsion is introduced in the fabrication of emulsion-based particles and that the stability of encapsulated proteins can be enhanced to an unprecedentedly high level.
An "osmo-solidification" approach that solidifies all-aqueous emulsion droplets for encapsulating proteins with superior preservation of their activity.</description><subject>Biochemistry</subject><subject>Biology</subject><subject>Droplets</subject><subject>Emulsions</subject><subject>Encapsulation</subject><subject>Preservation</subject><subject>Proteins</subject><subject>Solidification</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkctLw0AQxhdRrNRevCs5ihDdV_ZxrMUXFHqpIF7CZjOhK3nU7KbS_97U1nh0L7PM_Gb45huELgi-JZjpO5uEDFOipDlCZxQnOJYJUcfDH7-N0MT7D9w_RYRi_BSNGKWCainO0PvCV03sm9LlrnDWBNfUUVNEpixj89lB0_kIqq70u_yXC6sI6pWpLeTRugUP7WZoWbdNAFdHxga3cWF7jk4KU3qYHOIYvT4-LGfP8Xzx9DKbzmPLOA0xUKo1FpqyRGQF4QpkQSzh2jLJlBCi30MBMJtxDnme64RpKgurjaSSUsvG6Ho_txfQK_YhrZy3UJam3slPKVNSJERI8S9KFMZcEc5Ij97sUds23rdQpOvWVabdpgSnO-fTWbK8_3F-2sNXh7ldVkE-oL8-98DlHmi9Hap_p2PfXH2Hxw</recordid><startdate>20160221</startdate><enddate>20160221</enddate><creator>Ma, Qingming</creator><creator>Song, Yang</creator><creator>Baier, Grit</creator><creator>Holtze, Christian</creator><creator>Shum, Ho Cheung</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20160221</creationdate><title>Osmo-solidification of all-aqueous emulsion with enhanced preservation of protein activity</title><author>Ma, Qingming ; Song, Yang ; Baier, Grit ; Holtze, Christian ; Shum, Ho Cheung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-e22990692356bf148e7f1c149c37386660508ee3cb44eddd953927fc9a72722c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biochemistry</topic><topic>Biology</topic><topic>Droplets</topic><topic>Emulsions</topic><topic>Encapsulation</topic><topic>Preservation</topic><topic>Proteins</topic><topic>Solidification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Qingming</creatorcontrib><creatorcontrib>Song, Yang</creatorcontrib><creatorcontrib>Baier, Grit</creatorcontrib><creatorcontrib>Holtze, Christian</creatorcontrib><creatorcontrib>Shum, Ho Cheung</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Qingming</au><au>Song, Yang</au><au>Baier, Grit</au><au>Holtze, Christian</au><au>Shum, Ho Cheung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osmo-solidification of all-aqueous emulsion with enhanced preservation of protein activity</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2016-02-21</date><risdate>2016</risdate><volume>4</volume><issue>7</issue><spage>1213</spage><epage>1218</epage><pages>1213-1218</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>The encapsulation of bio-active ingredients, such as proteins, in solidified particles
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emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of non-aqueous solvents and unfavorable conditions during the solidification process. Herein, we introduce an "osmo-solidification" approach that solidifies all-aqueous emulsion droplets by the osmotic extraction of water for encapsulating proteins and demonstrate the superior preservation of their activity. The osmo-solidification approach combines the solidification of droplets to particles and protein encapsulation in one step. Proteins encapsulated preserve their activity after osmo-solidification better than conventional solidification approaches. To the best of our knowledge, this is the first time that the osmo-solidification of all-aqueous emulsion is introduced in the fabrication of emulsion-based particles and that the stability of encapsulated proteins can be enhanced to an unprecedentedly high level.
An "osmo-solidification" approach that solidifies all-aqueous emulsion droplets for encapsulating proteins with superior preservation of their activity.</abstract><cop>England</cop><pmid>32262976</pmid><doi>10.1039/c5tb02187a</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2016-02, Vol.4 (7), p.1213-1218 |
| issn | 2050-750X 2050-7518 |
| language | eng |
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| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Biochemistry Biology Droplets Emulsions Encapsulation Preservation Proteins Solidification |
| title | Osmo-solidification of all-aqueous emulsion with enhanced preservation of protein activity |
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