An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications

Sequestering peptides derived from the N-terminal heptad repeat (NHR) of class I viral fusion proteins into a non-aggregating trimeric coiled-coil conformation remains a major challenge. Here, we implemented a synthetic strategy to stabilize NHR-helical trimers, with the human immunodeficiency virus...

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Veröffentlicht in:	Chemical science (Cambridge) 2016-03, Vol.7 (3), p.2145-215
Hauptverfasser:	Lai, Wenqing, Wang, Chao, Yu, Fei, Lu, Lu, Wang, Qian, Jiang, Xifeng, Xu, Xiaoyu, Zhang, Tianhong, Wu, Shengming, Zheng, Xi, Zhang, Zhenqing, Dong, Fangting, Jiang, Shibo, Liu, Keliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Coiling Helical Human immunodeficiency virus Human immunodeficiency virus 1 Peptides Proteins Strategy Trimers Viruses
Online-Zugang:	Volltext
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