Radiosynthesis and evaluation of N-(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(4-fluorophenyl)thiazol-2-yl]-1-[11C]carboxamide for in vivo positron emission tomography imaging of fatty acid amide hydrolase in brain

We developed a novel positron emission tomography (PET) radiotracer N -(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(4-fluorophenyl)thiazol-2-yl]-1-[ 11 C]carboxamide ([ 11 C]DPFC, [ 11 C] 1 ) for in vivo imaging of fatty acid amide hydrolase (FAAH) in rat brain. Compound 1 showed a high binding affin...

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Veröffentlicht in:	RSC advances 2015-01, Vol.5 (128), p.16122-16127
Hauptverfasser:	Shimoda, Y, Yui, J, Zhang, Y, Hatori, A, Ogawa, M, Fujinaga, M, Yamasaki, T, Xie, L, Kumata, K, Zhang, M.-R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Brain Fatty acids Imaging Positron emission Radioactivity Tomography Uptakes
Online-Zugang:	Volltext
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