Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming

The protein synthesis machinery of the cell, the ribosome and associated factors, is able to accurately follow the canonical genetic code, that which maps RNA sequence to protein sequence, to assemble functional proteins from the twenty or so proteinogenic amino acids. A number of innovative methods...

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Veröffentlicht in:	Organic & biomolecular chemistry 2015-01, Vol.13 (36), p.9353-9363
Hauptverfasser:	Rogers, J. M, Suga, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Amino Acids - metabolism Amino Acyl-tRNA Synthetases - genetics Amino Acyl-tRNA Synthetases - metabolism Dose-Response Relationship, Drug Genetic Code Genetic Engineering Molecular Structure Peptide Library Peptides - chemistry Peptides - metabolism RNA, Catalytic - genetics RNA, Catalytic - metabolism Structure-Activity Relationship
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