Discovery of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has emerged as an attractive strategy for the treatment of cancer. Herein, we describe the design, synthesis, and biological evaluation of anilinopyr...

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Veröffentlicht in:	MedChemComm 2015-01, Vol.6 (7), p.1375-1380
Hauptverfasser:	Lv, Yongcong, Li, Mengyuan, Cao, Sufen, Tong, Linjiang, Peng, Ting, Wei, Lixin, Xie, Hua, Ding, Jian, Duan, Wenhu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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