Nutritional marginal zinc deficiency disrupts placental 11β-hydroxysteroid dehydrogenase type 2 modulation

This paper investigated if marginal zinc nutrition during gestation could affect fetal exposure to glucocorticoids as a consequence of a deregulation of placental 11βHSD2 expression. Placenta 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) plays a central role as a barrier protecting the fetus fro...

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Veröffentlicht in:	Food & function 2016-01, Vol.7 (1), p.84-92
Hauptverfasser:	Huang, Y. L, Supasai, S, Kucera, H, Gaikwad, N. W, Adamo, A. M, Mathieu, P, Oteiza, P. I
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 2 - analysis 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism Animals Diet Female Gene Expression - physiology Gestational Age Glucocorticoids - analysis Male Maternal Nutritional Physiological Phenomena Mitogen-Activated Protein Kinase 1 - physiology Mitogen-Activated Protein Kinase 3 - physiology p38 Mitogen-Activated Protein Kinases - physiology Placenta - chemistry Placenta - enzymology Pregnancy Rats Rats, Sprague-Dawley RNA, Messenger - analysis Signal Transduction Zinc - administration & dosage Zinc - deficiency
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