Novel metronidazole-sulfonamide derivatives as potent and selective carbonic anhydrase inhibitors: design, synthesis and biology analysis

Metronidazole-sulfonamide derivatives 4a-4l , a new class of human carbonic anhydrase inhibitors (hCA), were designed, synthesized, isolated, and evaluated for their ability to inhibit the enzymatic activity of the physiologically dominant isozymes hCA II and the tumor-associated isozyme hCA IX (h =...

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Veröffentlicht in:	RSC advances 2014-01, Vol.4 (62), p.3329-3338
Hauptverfasser:	Wang, Zhong-Chang, Duan, Yong-Tao, Qiu, Han-Yue, Huang, Wan-Yun, Wang, Peng-Fei, Yan, Xiao-Qiang, Zhang, Shu-Feng, Zhu, Hai-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Biotechnology Carbonic anhydrase Derivatives Design analysis Human performance Inhibitors Synthesis
Online-Zugang:	Volltext
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