Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes

Ene-reductases (ERs) are flavin dependent enzymes that catalyze the asymmetric reduction of activated carbon-carbon double bonds. In particular, α,β-unsaturated carbonyl compounds (e.g. enals and enones) as well as nitroalkenes are rapidly reduced. Conversely, α,β-unsaturated esters are poorly accep...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-01, Vol.13 (1), p.223-233
Hauptverfasser: Knaus, Tanja, Mutti, Francesco G, Humphreys, Luke D, Turner, Nicholas J, Scrutton, Nigel S
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Sprache:eng
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