Developing piperine towards TRPV1 and GABA A receptor ligands – synthesis of piperine analogs via Heck-coupling of conjugated dienes

Piperine, the pungent alkaloid of black pepper, and several of its derivatives are modulators of γ-amino butyric acid type A (GABA A ) receptors. Concomitantly, this natural product has also been reported to activate transient receptor potential vanilloid type 1 (TRPV1) receptors. We have developed...

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Veröffentlicht in:	Organic & biomolecular chemistry 2015, Vol.13 (4), p.990-994
Hauptverfasser:	Wimmer, Laurin, Schönbauer, David, Pakfeifer, Peter, Schöffmann, Angela, Khom, Sophia, Hering, Steffen, Mihovilovic, Marko D.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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