Synthesis and biological evaluation of dual action cyclo -RGD/SMAC mimetic conjugates targeting α v β 3 /α v β 5 integrins and IAP proteins

The rational design, synthesis and in vitro biological evaluation of dual action conjugates 11–13 , containing a tumour targeting, integrin α v β 3 /α v β 5 ligand portion and a pro-apoptotic SMAC mimetic portion ( cyclo -RGD/SMAC mimetic conjugates) are reported. The binding strength of the two sep...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic & biomolecular chemistry 2014, Vol.12 (20), p.3288-3302
Hauptverfasser:	Mingozzi, M., Manzoni, L., Arosio, D., Dal Corso, A., Manzotti, M., Innamorati, F., Pignataro, L., Lecis, D., Delia, D., Seneci, P., Gennari, C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!