Synthesis and biological evaluation of a novel class of β-carboline derivatives
In this study, several novel β-carboline derivatives, 1-(4-hydroxy-3-methoxyphenyl)-β-carboline-3-carboxyl-Trp-Trp-AA-OBzl compounds, were designed and synthesized as potential anticancer agents. Their in vitro cytotoxic activities were evaluated using methylthiazoltetrazolium (MTT) assay. The in vi...
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| Veröffentlicht in: | New journal of chemistry 2014, Vol.38 (9), p.4155-4166 |
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| container_end_page | 4166 |
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| container_issue | 9 |
| container_start_page | 4155 |
| container_title | New journal of chemistry |
| container_volume | 38 |
| creator | Chen, Hao Gao, Pengchao Zhang, Meng Liao, Wei Zhang, Jianwei |
| description | In this study, several novel β-carboline derivatives, 1-(4-hydroxy-3-methoxyphenyl)-β-carboline-3-carboxyl-Trp-Trp-AA-OBzl compounds, were designed and synthesized as potential anticancer agents. Their
in vitro
cytotoxic activities were evaluated using methylthiazoltetrazolium (MTT) assay. The
in vivo
anti-tumor activity of the newly synthesized β-carboline derivatives was determined in a S180 bearing mouse model and some of the compounds demonstrated tumor growth inhibition similar to the positive control, doxorubicin. The intercalation of the β-carboline derivatives synthesized with calf thymus (CT) DNA was also studied. |
| doi_str_mv | 10.1039/C4NJ00262H |
| format | Article |
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in vitro
cytotoxic activities were evaluated using methylthiazoltetrazolium (MTT) assay. The
in vivo
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in vitro
cytotoxic activities were evaluated using methylthiazoltetrazolium (MTT) assay. The
in vivo
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in vitro
cytotoxic activities were evaluated using methylthiazoltetrazolium (MTT) assay. The
in vivo
anti-tumor activity of the newly synthesized β-carboline derivatives was determined in a S180 bearing mouse model and some of the compounds demonstrated tumor growth inhibition similar to the positive control, doxorubicin. The intercalation of the β-carboline derivatives synthesized with calf thymus (CT) DNA was also studied.</abstract><doi>10.1039/C4NJ00262H</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2014, Vol.38 (9), p.4155-4166 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Synthesis and biological evaluation of a novel class of β-carboline derivatives |
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