Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors

A series of forty-five 1,5-diphenylpenta-2,4-dien-1-one analogues were synthesized and evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 cells. Compounds 3h , 7a , 7d and 7e exhibited comparable or significantly higher activity than the standard, curcumin (IC...

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Veröffentlicht in:	MedChemComm 2015, Vol.6 (6), p.1069-1080
Hauptverfasser:	Mohd Faudzi, S. M., Leong, S. W., Abas, F., Mohd Aluwi, M. F. F., Rullah, K., Lam, K. W., Ahmad, S., Tham, C. L., Shaari, K., Lajis, N. H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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