Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

The 140 residue intrinsically disordered protein α-synuclein (α-syn) self-associates to form fibrils that are the major constituent of the Lewy body intracellular protein inclusions, and neurotoxic oligomers. Both of these macromolecular structures are associated with a number of neurodegenerative d...

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Veröffentlicht in:	Molecular bioSystems 2015-01, Vol.11 (1), p.190-196
Hauptverfasser:	Curtain, Cyril C, Kirby, Nigel M, Mertens, Haydyn D T, Barnham, Kevin J, Knott, Robert B, Masters, Colin L, Cappai, Roberto, Rekas, Agata, Kenche, Vijaya B, Ryan, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics Amino Acid Substitution Models, Molecular Mutation Protein Conformation Protein Multimerization Structure-Activity Relationship
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