Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation
Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity. (Poly)phenols (PPs), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis. The objective of this study was to test the antibacterial...
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| Veröffentlicht in: | Food & function 2015-03, Vol.6 (3), p.719-729 |
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| creator | Shahzad, Muhammad Millhouse, Emma Culshaw, Shauna Edwards, Christine A Ramage, Gordon Combet, Emilie |
| description | Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity. (Poly)phenols (PPs), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis. The objective of this study was to test the antibacterial effects of selected PPs on periodontal pathogens, on both planktonic and biofilm modes of growth. Selected PPs (
n
= 48) were screened against
Streptococcus mitis (S. mitis), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Fusobacterium nucleatum (F. nucleatum)
and
Porphyromonas gingivalis (P. gingivalis)
. The antibacterial potential of each compound was evaluated in terms of planktonic minimum inhibitory concentration (PMIC) and planktonic minimum bactericidal concentration (PMBC) using standardized broth microdilution assays. The most active PPs were further tested for their effect on mono-species and multi-species biofilms using a colorimetric resazurin-based viability assay and scanning electron microscopy. Of the 48 PPs tested, 43 showed effective inhibition of planktonic growth of one or more test strains, of which curcumin was the most potent (PMIC range = 7.8-62.5 μg mL
−1
), followed by pyrogallol (PMIC range = 2.4-2500 μg mL
−1
), pyrocatechol (MIC range = 4.9-312.5 μg mL
−1
) and quercetin (PMIC range = 31.2-500 μg mL
−1
). At this concentration, adhesion of curcumin and quercetin to the substrate also inhibited adhesion of
S. mitis
, and biofilm formation and maturation. While both curcumin and quercetin were able to alter architecture of mature multi-species biofilms, only curcumin-treated biofilms displayed a significantly reduced metabolic activity. Overall, PPs possess antibacterial activities against periodontopathic bacteria in both planktonic and biofilm modes of growth. Further cellular and
in vivo
studies are necessary to confirm their beneficial activities and potential use in the prevention and or treatment of periodontal diseases.
Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity. |
| doi_str_mv | 10.1039/c4fo01087f |
| format | Article |
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n
= 48) were screened against
Streptococcus mitis (S. mitis), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Fusobacterium nucleatum (F. nucleatum)
and
Porphyromonas gingivalis (P. gingivalis)
. The antibacterial potential of each compound was evaluated in terms of planktonic minimum inhibitory concentration (PMIC) and planktonic minimum bactericidal concentration (PMBC) using standardized broth microdilution assays. The most active PPs were further tested for their effect on mono-species and multi-species biofilms using a colorimetric resazurin-based viability assay and scanning electron microscopy. Of the 48 PPs tested, 43 showed effective inhibition of planktonic growth of one or more test strains, of which curcumin was the most potent (PMIC range = 7.8-62.5 μg mL
−1
), followed by pyrogallol (PMIC range = 2.4-2500 μg mL
−1
), pyrocatechol (MIC range = 4.9-312.5 μg mL
−1
) and quercetin (PMIC range = 31.2-500 μg mL
−1
). At this concentration, adhesion of curcumin and quercetin to the substrate also inhibited adhesion of
S. mitis
, and biofilm formation and maturation. While both curcumin and quercetin were able to alter architecture of mature multi-species biofilms, only curcumin-treated biofilms displayed a significantly reduced metabolic activity. Overall, PPs possess antibacterial activities against periodontopathic bacteria in both planktonic and biofilm modes of growth. Further cellular and
in vivo
studies are necessary to confirm their beneficial activities and potential use in the prevention and or treatment of periodontal diseases.
Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/c4fo01087f</identifier><identifier>PMID: 25585200</identifier><language>eng</language><publisher>England</publisher><subject><![CDATA[Adsorption ; Aggregatibacter actinomycetemcomitans - drug effects ; Aggregatibacter actinomycetemcomitans - growth & development ; Aggregatibacter actinomycetemcomitans - physiology ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Bacterial Adhesion - drug effects ; Biofilms - drug effects ; Biofilms - growth & development ; Catechols - chemistry ; Catechols - pharmacology ; Curcumin - chemistry ; Curcumin - pharmacology ; Durapatite - chemistry ; Fusobacterium nucleatum ; Fusobacterium nucleatum - drug effects ; Fusobacterium nucleatum - growth & development ; Fusobacterium nucleatum - physiology ; Humans ; Microbial Sensitivity Tests ; Microbial Viability - drug effects ; Mouthwashes - chemistry ; Mouthwashes - pharmacology ; Periodontitis - drug therapy ; Periodontitis - immunology ; Periodontitis - microbiology ; Periodontitis - prevention & control ; Polyphenols - chemistry ; Polyphenols - pharmacology ; Porphyromonas gingivalis ; Porphyromonas gingivalis - drug effects ; Porphyromonas gingivalis - growth & development ; Porphyromonas gingivalis - physiology ; Pyrogallol - chemistry ; Pyrogallol - pharmacology ; Quercetin - chemistry ; Quercetin - pharmacology ; Streptococcus mitis ; Streptococcus mitis - drug effects ; Streptococcus mitis - growth & development ; Streptococcus mitis - physiology ; Structure-Activity Relationship]]></subject><ispartof>Food & function, 2015-03, Vol.6 (3), p.719-729</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-cd907532dec4023272fdf45948c3334c32b5564b8315cbc77a42a1efa07bb4323</citedby><cites>FETCH-LOGICAL-c511t-cd907532dec4023272fdf45948c3334c32b5564b8315cbc77a42a1efa07bb4323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25585200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shahzad, Muhammad</creatorcontrib><creatorcontrib>Millhouse, Emma</creatorcontrib><creatorcontrib>Culshaw, Shauna</creatorcontrib><creatorcontrib>Edwards, Christine A</creatorcontrib><creatorcontrib>Ramage, Gordon</creatorcontrib><creatorcontrib>Combet, Emilie</creatorcontrib><title>Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity. (Poly)phenols (PPs), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis. The objective of this study was to test the antibacterial effects of selected PPs on periodontal pathogens, on both planktonic and biofilm modes of growth. Selected PPs (
n
= 48) were screened against
Streptococcus mitis (S. mitis), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Fusobacterium nucleatum (F. nucleatum)
and
Porphyromonas gingivalis (P. gingivalis)
. The antibacterial potential of each compound was evaluated in terms of planktonic minimum inhibitory concentration (PMIC) and planktonic minimum bactericidal concentration (PMBC) using standardized broth microdilution assays. The most active PPs were further tested for their effect on mono-species and multi-species biofilms using a colorimetric resazurin-based viability assay and scanning electron microscopy. Of the 48 PPs tested, 43 showed effective inhibition of planktonic growth of one or more test strains, of which curcumin was the most potent (PMIC range = 7.8-62.5 μg mL
−1
), followed by pyrogallol (PMIC range = 2.4-2500 μg mL
−1
), pyrocatechol (MIC range = 4.9-312.5 μg mL
−1
) and quercetin (PMIC range = 31.2-500 μg mL
−1
). At this concentration, adhesion of curcumin and quercetin to the substrate also inhibited adhesion of
S. mitis
, and biofilm formation and maturation. While both curcumin and quercetin were able to alter architecture of mature multi-species biofilms, only curcumin-treated biofilms displayed a significantly reduced metabolic activity. Overall, PPs possess antibacterial activities against periodontopathic bacteria in both planktonic and biofilm modes of growth. Further cellular and
in vivo
studies are necessary to confirm their beneficial activities and potential use in the prevention and or treatment of periodontal diseases.
Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity.</description><subject>Adsorption</subject><subject>Aggregatibacter actinomycetemcomitans - drug effects</subject><subject>Aggregatibacter actinomycetemcomitans - growth & development</subject><subject>Aggregatibacter actinomycetemcomitans - physiology</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Adhesion - drug effects</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Catechols - chemistry</subject><subject>Catechols - pharmacology</subject><subject>Curcumin - chemistry</subject><subject>Curcumin - pharmacology</subject><subject>Durapatite - chemistry</subject><subject>Fusobacterium nucleatum</subject><subject>Fusobacterium nucleatum - drug effects</subject><subject>Fusobacterium nucleatum - growth & development</subject><subject>Fusobacterium nucleatum - physiology</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbial Viability - drug effects</subject><subject>Mouthwashes - chemistry</subject><subject>Mouthwashes - pharmacology</subject><subject>Periodontitis - drug therapy</subject><subject>Periodontitis - immunology</subject><subject>Periodontitis - microbiology</subject><subject>Periodontitis - prevention & control</subject><subject>Polyphenols - chemistry</subject><subject>Polyphenols - pharmacology</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - drug effects</subject><subject>Porphyromonas gingivalis - growth & development</subject><subject>Porphyromonas gingivalis - physiology</subject><subject>Pyrogallol - chemistry</subject><subject>Pyrogallol - pharmacology</subject><subject>Quercetin - chemistry</subject><subject>Quercetin - pharmacology</subject><subject>Streptococcus mitis</subject><subject>Streptococcus mitis - drug effects</subject><subject>Streptococcus mitis - growth & development</subject><subject>Streptococcus mitis - physiology</subject><subject>Structure-Activity Relationship</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtLAzEURoMottRu3CtxV4VqnvNYSrEqFLpQobshk0cbmZmMSYr03zvahzvxbu6F7_AtzgXgHKNbjGh-J5lxCKMsNUegTxAj44SjxfH-ZnnSA8MQ3lE3NM-zPDsFPcJ5xglCfbB40ZWWUSuorI7Cb-CoddXmul3pxlUB2mZlSxthq711yjVRVLAVceWWuoFL7z7jCopGwdI6Y6saGudrEa1rzsCJEVXQw90egLfpw-vkaTybPz5P7mdjyTGOY6lylHJKlJYMEUpSYpRhPGeZpJQySUnJecLKjGIuS5mmghGBtREoLUtGCR2A0ba39e5jrUMsahukrirRaLcOBU6SjCSM4n-hNOEcobRDb7ao9C4Er03Relt3egqMim_vxYRN5z_epx18uetdl7VWB3RvuQMutoAP8pD-Pq7Lr_7Ki1YZ-gXSlZJ1</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Shahzad, Muhammad</creator><creator>Millhouse, Emma</creator><creator>Culshaw, Shauna</creator><creator>Edwards, Christine A</creator><creator>Ramage, Gordon</creator><creator>Combet, Emilie</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150301</creationdate><title>Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation</title><author>Shahzad, Muhammad ; Millhouse, Emma ; Culshaw, Shauna ; Edwards, Christine A ; Ramage, Gordon ; Combet, Emilie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-cd907532dec4023272fdf45948c3334c32b5564b8315cbc77a42a1efa07bb4323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adsorption</topic><topic>Aggregatibacter actinomycetemcomitans - drug effects</topic><topic>Aggregatibacter actinomycetemcomitans - growth & development</topic><topic>Aggregatibacter actinomycetemcomitans - physiology</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Adhesion - drug effects</topic><topic>Biofilms - drug effects</topic><topic>Biofilms - growth & development</topic><topic>Catechols - chemistry</topic><topic>Catechols - pharmacology</topic><topic>Curcumin - chemistry</topic><topic>Curcumin - pharmacology</topic><topic>Durapatite - chemistry</topic><topic>Fusobacterium nucleatum</topic><topic>Fusobacterium nucleatum - drug effects</topic><topic>Fusobacterium nucleatum - growth & development</topic><topic>Fusobacterium nucleatum - physiology</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbial Viability - drug effects</topic><topic>Mouthwashes - chemistry</topic><topic>Mouthwashes - pharmacology</topic><topic>Periodontitis - drug therapy</topic><topic>Periodontitis - immunology</topic><topic>Periodontitis - microbiology</topic><topic>Periodontitis - prevention & control</topic><topic>Polyphenols - chemistry</topic><topic>Polyphenols - pharmacology</topic><topic>Porphyromonas gingivalis</topic><topic>Porphyromonas gingivalis - drug effects</topic><topic>Porphyromonas gingivalis - growth & development</topic><topic>Porphyromonas gingivalis - physiology</topic><topic>Pyrogallol - chemistry</topic><topic>Pyrogallol - pharmacology</topic><topic>Quercetin - chemistry</topic><topic>Quercetin - pharmacology</topic><topic>Streptococcus mitis</topic><topic>Streptococcus mitis - drug effects</topic><topic>Streptococcus mitis - growth & development</topic><topic>Streptococcus mitis - physiology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shahzad, Muhammad</creatorcontrib><creatorcontrib>Millhouse, Emma</creatorcontrib><creatorcontrib>Culshaw, Shauna</creatorcontrib><creatorcontrib>Edwards, Christine A</creatorcontrib><creatorcontrib>Ramage, Gordon</creatorcontrib><creatorcontrib>Combet, Emilie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shahzad, Muhammad</au><au>Millhouse, Emma</au><au>Culshaw, Shauna</au><au>Edwards, Christine A</au><au>Ramage, Gordon</au><au>Combet, Emilie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>6</volume><issue>3</issue><spage>719</spage><epage>729</epage><pages>719-729</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity. (Poly)phenols (PPs), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis. The objective of this study was to test the antibacterial effects of selected PPs on periodontal pathogens, on both planktonic and biofilm modes of growth. Selected PPs (
n
= 48) were screened against
Streptococcus mitis (S. mitis), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Fusobacterium nucleatum (F. nucleatum)
and
Porphyromonas gingivalis (P. gingivalis)
. The antibacterial potential of each compound was evaluated in terms of planktonic minimum inhibitory concentration (PMIC) and planktonic minimum bactericidal concentration (PMBC) using standardized broth microdilution assays. The most active PPs were further tested for their effect on mono-species and multi-species biofilms using a colorimetric resazurin-based viability assay and scanning electron microscopy. Of the 48 PPs tested, 43 showed effective inhibition of planktonic growth of one or more test strains, of which curcumin was the most potent (PMIC range = 7.8-62.5 μg mL
−1
), followed by pyrogallol (PMIC range = 2.4-2500 μg mL
−1
), pyrocatechol (MIC range = 4.9-312.5 μg mL
−1
) and quercetin (PMIC range = 31.2-500 μg mL
−1
). At this concentration, adhesion of curcumin and quercetin to the substrate also inhibited adhesion of
S. mitis
, and biofilm formation and maturation. While both curcumin and quercetin were able to alter architecture of mature multi-species biofilms, only curcumin-treated biofilms displayed a significantly reduced metabolic activity. Overall, PPs possess antibacterial activities against periodontopathic bacteria in both planktonic and biofilm modes of growth. Further cellular and
in vivo
studies are necessary to confirm their beneficial activities and potential use in the prevention and or treatment of periodontal diseases.
Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity.</abstract><cop>England</cop><pmid>25585200</pmid><doi>10.1039/c4fo01087f</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Food & function, 2015-03, Vol.6 (3), p.719-729 |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Adsorption Aggregatibacter actinomycetemcomitans - drug effects Aggregatibacter actinomycetemcomitans - growth & development Aggregatibacter actinomycetemcomitans - physiology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Adhesion - drug effects Biofilms - drug effects Biofilms - growth & development Catechols - chemistry Catechols - pharmacology Curcumin - chemistry Curcumin - pharmacology Durapatite - chemistry Fusobacterium nucleatum Fusobacterium nucleatum - drug effects Fusobacterium nucleatum - growth & development Fusobacterium nucleatum - physiology Humans Microbial Sensitivity Tests Microbial Viability - drug effects Mouthwashes - chemistry Mouthwashes - pharmacology Periodontitis - drug therapy Periodontitis - immunology Periodontitis - microbiology Periodontitis - prevention & control Polyphenols - chemistry Polyphenols - pharmacology Porphyromonas gingivalis Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - growth & development Porphyromonas gingivalis - physiology Pyrogallol - chemistry Pyrogallol - pharmacology Quercetin - chemistry Quercetin - pharmacology Streptococcus mitis Streptococcus mitis - drug effects Streptococcus mitis - growth & development Streptococcus mitis - physiology Structure-Activity Relationship |
| title | Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation |
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