Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T 1 MR images in a 1.5 T MR field
The dependence of longitudinal ( r 1 ) and transverse ( r 2 ) water proton relaxivities of ultrasmall gadolinium oxide (Gd 2 O 3 ) nanoparticles on the surface coating ligand-size was investigated. Both r 1 and r 2 values decreased with increasing ligand-size. We attributed this to the ligand-size e...
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| Veröffentlicht in: | Physical chemistry chemical physics : PCCP 2014, Vol.16 (37), p.19866-19873 |
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| container_end_page | 19873 |
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| container_issue | 37 |
| container_start_page | 19866 |
| container_title | Physical chemistry chemical physics : PCCP |
| container_volume | 16 |
| creator | Kim, Cho Rong Baeck, Jong Su Chang, Yongmin Bae, Ji Eun Chae, Kwon Seok Lee, Gang Ho |
| description | The dependence of longitudinal (
r
1
) and transverse (
r
2
) water proton relaxivities of ultrasmall gadolinium oxide (Gd
2
O
3
) nanoparticles on the surface coating ligand-size was investigated. Both
r
1
and
r
2
values decreased with increasing ligand-size. We attributed this to the ligand-size effect. In addition the effectiveness of
d
-glucuronic acid-coated ultrasmall Gd
2
O
3
nanoparticles as
T
1
magnetic resonance imaging (MRI) contrast agents was confirmed by measuring the
in vitro
cytotoxicity and using
in vivo T
1
MR images in a mouse in a 1.5 T MR field. |
| doi_str_mv | 10.1039/C4CP01946F |
| format | Article |
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r
1
) and transverse (
r
2
) water proton relaxivities of ultrasmall gadolinium oxide (Gd
2
O
3
) nanoparticles on the surface coating ligand-size was investigated. Both
r
1
and
r
2
values decreased with increasing ligand-size. We attributed this to the ligand-size effect. In addition the effectiveness of
d
-glucuronic acid-coated ultrasmall Gd
2
O
3
nanoparticles as
T
1
magnetic resonance imaging (MRI) contrast agents was confirmed by measuring the
in vitro
cytotoxicity and using
in vivo T
1
MR images in a mouse in a 1.5 T MR field.</description><identifier>ISSN: 1463-9076</identifier><identifier>EISSN: 1463-9084</identifier><identifier>DOI: 10.1039/C4CP01946F</identifier><language>eng</language><ispartof>Physical chemistry chemical physics : PCCP, 2014, Vol.16 (37), p.19866-19873</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c161t-b5b96df50f0e073985cafb3dbb531f4f645984e44278d620b41d2c62a746e7ea3</citedby><cites>FETCH-LOGICAL-c161t-b5b96df50f0e073985cafb3dbb531f4f645984e44278d620b41d2c62a746e7ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Kim, Cho Rong</creatorcontrib><creatorcontrib>Baeck, Jong Su</creatorcontrib><creatorcontrib>Chang, Yongmin</creatorcontrib><creatorcontrib>Bae, Ji Eun</creatorcontrib><creatorcontrib>Chae, Kwon Seok</creatorcontrib><creatorcontrib>Lee, Gang Ho</creatorcontrib><title>Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T 1 MR images in a 1.5 T MR field</title><title>Physical chemistry chemical physics : PCCP</title><description>The dependence of longitudinal (
r
1
) and transverse (
r
2
) water proton relaxivities of ultrasmall gadolinium oxide (Gd
2
O
3
) nanoparticles on the surface coating ligand-size was investigated. Both
r
1
and
r
2
values decreased with increasing ligand-size. We attributed this to the ligand-size effect. In addition the effectiveness of
d
-glucuronic acid-coated ultrasmall Gd
2
O
3
nanoparticles as
T
1
magnetic resonance imaging (MRI) contrast agents was confirmed by measuring the
in vitro
cytotoxicity and using
in vivo T
1
MR images in a mouse in a 1.5 T MR field.</description><issn>1463-9076</issn><issn>1463-9084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpFkF9LwzAUxYMoOKcvfoI8C51J86ftoxTnhIki87mkzc2IZElJujn9CH5qOyb6dA-Hc35cDkLXlMwoYdVtzesXQisu5ydoQrlkWUVKfvqnC3mOLlJ6J4RQQdkEfS_tWnmdJfsFWEMPXoMf8IcaIOI-hiF4HMGpvd3ZwULC1uOtG6JKG-UcXisdnPV2u8FhbzVgr3zoVRxs58bwSD4UdnYX8ApT_PSK7UatjxiF6UyM9mgaC05fojOjXIKr3ztFb_P7Vb3Ils8Pj_XdMuuopEPWiraS2ghiCJCCVaXolGmZblvBqOFGclGVHDjPi1LLnLSc6ryTuSq4hAIUm6KbI7eLIaUIpunj-FX8bChpDis2_yuyHzqfZZk</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Kim, Cho Rong</creator><creator>Baeck, Jong Su</creator><creator>Chang, Yongmin</creator><creator>Bae, Ji Eun</creator><creator>Chae, Kwon Seok</creator><creator>Lee, Gang Ho</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2014</creationdate><title>Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T 1 MR images in a 1.5 T MR field</title><author>Kim, Cho Rong ; Baeck, Jong Su ; Chang, Yongmin ; Bae, Ji Eun ; Chae, Kwon Seok ; Lee, Gang Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c161t-b5b96df50f0e073985cafb3dbb531f4f645984e44278d620b41d2c62a746e7ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Cho Rong</creatorcontrib><creatorcontrib>Baeck, Jong Su</creatorcontrib><creatorcontrib>Chang, Yongmin</creatorcontrib><creatorcontrib>Bae, Ji Eun</creatorcontrib><creatorcontrib>Chae, Kwon Seok</creatorcontrib><creatorcontrib>Lee, Gang Ho</creatorcontrib><collection>CrossRef</collection><jtitle>Physical chemistry chemical physics : PCCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Cho Rong</au><au>Baeck, Jong Su</au><au>Chang, Yongmin</au><au>Bae, Ji Eun</au><au>Chae, Kwon Seok</au><au>Lee, Gang Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T 1 MR images in a 1.5 T MR field</atitle><jtitle>Physical chemistry chemical physics : PCCP</jtitle><date>2014</date><risdate>2014</risdate><volume>16</volume><issue>37</issue><spage>19866</spage><epage>19873</epage><pages>19866-19873</pages><issn>1463-9076</issn><eissn>1463-9084</eissn><abstract>The dependence of longitudinal (
r
1
) and transverse (
r
2
) water proton relaxivities of ultrasmall gadolinium oxide (Gd
2
O
3
) nanoparticles on the surface coating ligand-size was investigated. Both
r
1
and
r
2
values decreased with increasing ligand-size. We attributed this to the ligand-size effect. In addition the effectiveness of
d
-glucuronic acid-coated ultrasmall Gd
2
O
3
nanoparticles as
T
1
magnetic resonance imaging (MRI) contrast agents was confirmed by measuring the
in vitro
cytotoxicity and using
in vivo T
1
MR images in a mouse in a 1.5 T MR field.</abstract><doi>10.1039/C4CP01946F</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1463-9076 |
| ispartof | Physical chemistry chemical physics : PCCP, 2014, Vol.16 (37), p.19866-19873 |
| issn | 1463-9076 1463-9084 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C4CP01946F |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T 1 MR images in a 1.5 T MR field |
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