Micro- and nanoparticles for treating cardiovascular disease
Cardiovascular disease, including myocardial infarction (MI) and peripheral artery disease (PAD), afflicts millions of people in Unites States. Current therapies are insufficient to restore blood flow and repair the injured heart or skeletal muscle, respectively, which is subjected to ischemic damag...
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| Veröffentlicht in: | Biomaterials science 2015-04, Vol.3 (4), p.564-58 |
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| creator | Suarez, S Almutairi, A Christman, K. L |
| description | Cardiovascular disease, including myocardial infarction (MI) and peripheral artery disease (PAD), afflicts millions of people in Unites States. Current therapies are insufficient to restore blood flow and repair the injured heart or skeletal muscle, respectively, which is subjected to ischemic damage following vessel occlusion. Micro- and nano-particles are being designed as delivery vehicles for growth factors, enzymes and/or small molecules to provide a sustained therapeutic stimulus at the injured tissue. Depending on the formulation, the particles can be injected directly into the heart or skeletal muscle, or accumulate at the site of injury following an intravenous injection. In this article we review existing particle based therapies for treating MI and PAD.
Micro- and nano-particles are being designed as delivery vehicles to provide a sustained therapeutic stimulus at the injured tissue. |
| doi_str_mv | 10.1039/c4bm00441h |
| format | Article |
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Micro- and nano-particles are being designed as delivery vehicles to provide a sustained therapeutic stimulus at the injured tissue.</description><subject>Cardiovascular Diseases - drug therapy</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Drug Delivery Systems - methods</subject><subject>Heart - drug effects</subject><subject>Humans</subject><subject>Injections, Intravenous - methods</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Peripheral Arterial Disease - therapy</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1Lw0AQxRdRrNRevCvxJkJ0tztJdkEELWoFixc9L5P90JU0qbtJwf_eaLXqxbnMwPvxZnhDyB6jJ4xyeaqhnFMKwJ43yM6YQpGCALm5njkdkFGML7SvopA0Z9tkMM4Z5BmIHXI28zo0aYK1SWqsmwWG1uvKxsQ1IWmDxdbXT4nGYHyzxKi7CkNifLQY7S7ZclhFO_rqQ_J4ffUwmaZ39ze3k4u7VIMct6mDcWFooYVwpTQgpKQG0JTIncxYSTVFiaWQTuYZItOCZSLjpUNpKNjM8iE5X_kuunJujbZ1G7BSi-DnGN5Ug179VWr_rJ6apQIQOc95b3D0ZRCa187GVs191LaqsLZNFxUrKM0Fz3Lo0eMV2scSY7BuvYZR9ZG4msDl7DPxaQ8f_D5sjX7n2wP7KyBEvVZ_Xtbrh__pamEcfwczsJIM</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Suarez, S</creator><creator>Almutairi, A</creator><creator>Christman, K. L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>Micro- and nanoparticles for treating cardiovascular disease</title><author>Suarez, S ; Almutairi, A ; Christman, K. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-f427d07c88fb9d48990d4adba3f951b0c0a9ab89f965aa1c815853bfa9d04e5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cardiovascular Diseases - drug therapy</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Drug Delivery Systems - methods</topic><topic>Heart - drug effects</topic><topic>Humans</topic><topic>Injections, Intravenous - methods</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Peripheral Arterial Disease - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suarez, S</creatorcontrib><creatorcontrib>Almutairi, A</creatorcontrib><creatorcontrib>Christman, K. L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suarez, S</au><au>Almutairi, A</au><au>Christman, K. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micro- and nanoparticles for treating cardiovascular disease</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>3</volume><issue>4</issue><spage>564</spage><epage>58</epage><pages>564-58</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>Cardiovascular disease, including myocardial infarction (MI) and peripheral artery disease (PAD), afflicts millions of people in Unites States. Current therapies are insufficient to restore blood flow and repair the injured heart or skeletal muscle, respectively, which is subjected to ischemic damage following vessel occlusion. Micro- and nano-particles are being designed as delivery vehicles for growth factors, enzymes and/or small molecules to provide a sustained therapeutic stimulus at the injured tissue. Depending on the formulation, the particles can be injected directly into the heart or skeletal muscle, or accumulate at the site of injury following an intravenous injection. In this article we review existing particle based therapies for treating MI and PAD.
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| fulltext | fulltext |
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| ispartof | Biomaterials science, 2015-04, Vol.3 (4), p.564-58 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Cardiovascular Diseases - drug therapy Cardiovascular Diseases - physiopathology Drug Delivery Systems - methods Heart - drug effects Humans Injections, Intravenous - methods Myocardial Infarction - drug therapy Myocardial Infarction - physiopathology Nanoparticles - administration & dosage Nanoparticles - chemistry Peripheral Arterial Disease - therapy |
| title | Micro- and nanoparticles for treating cardiovascular disease |
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