A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an important place in the field of medicinal inorganic chemistry due to their unique chemical properties with respect to gold co...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2014-03, Vol.43 (11), p.429-4219 |
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| container_title | Dalton transactions : an international journal of inorganic chemistry |
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| creator | Bertrand, Benoît Casini, Angela |
| description | From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an important place in the field of medicinal inorganic chemistry due to their unique chemical properties with respect to gold coordination compounds. In fact, several studies have proved that they can be used to develop highly efficient metal-based drugs with possible applications in the treatment of cancer. This Perspective summarizes the results obtained for different families of bioactive organometallic gold compounds including cyclometallated gold(
iii
) complexes with C,N-donor ligands, gold(
i
) and gold(
i
/
iii
) N-heterocyclic (NHC) carbene complexes, as well as gold(
i
) alkynyl complexes, with promising anticancer effects. Most importantly, we will focus on recent developments in the field and discuss the potential of this class of organometallic compounds in relation to their versatile chemistry and innovative mechanisms of action.
This review provides an overview of the recent results concerning anticancer organometallic gold compounds and related mechanistic insights. |
| doi_str_mv | 10.1039/c3dt52524d |
| format | Article |
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iii
) complexes with C,N-donor ligands, gold(
i
) and gold(
i
/
iii
) N-heterocyclic (NHC) carbene complexes, as well as gold(
i
) alkynyl complexes, with promising anticancer effects. Most importantly, we will focus on recent developments in the field and discuss the potential of this class of organometallic compounds in relation to their versatile chemistry and innovative mechanisms of action.
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iii
) complexes with C,N-donor ligands, gold(
i
) and gold(
i
/
iii
) N-heterocyclic (NHC) carbene complexes, as well as gold(
i
) alkynyl complexes, with promising anticancer effects. Most importantly, we will focus on recent developments in the field and discuss the potential of this class of organometallic compounds in relation to their versatile chemistry and innovative mechanisms of action.
This review provides an overview of the recent results concerning anticancer organometallic gold compounds and related mechanistic insights.</description><subject>Alkynes - chemistry</subject><subject>Alkynes - pharmacology</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Humans</subject><subject>Methane - analogs & derivatives</subject><subject>Methane - chemistry</subject><subject>Methane - pharmacology</subject><subject>Neoplasms - drug therapy</subject><subject>Organogold Compounds - chemistry</subject><subject>Organogold Compounds - pharmacology</subject><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EoqWwsIPMihSwHdtJ2KqUl1SJpcyRn61REkd2MvTfk7ZQNqZ7j-53jnQPANcYPWCUFo8q1T0jjFB9AqaYZllSkJSeHnfCJ-Aixi-ECEGMnIMJoYQwzrMpcHO49rU2LbRDPwQDXQsbo51yrahH4cNatE5BtTGNi33YPsF-Y2AX_CgN9BaKtndKtMqEfRLcO3xjelHXO6NvOj-0Ol6CMyvqaK5-5gx8vjyvyrdk-fH6Xs6XiaKU9IlRSskiL7gkVrKsyDU3GbUa6YxjKzLJckIxp5wyRbDkaW4wZ0YhriSWRqQzcH_IVcHHGIytuuAaEbYVRtWur6pMF6t9X4sRvj3A3SDHt4_ob0EjcHcAQlTH61_hVaftyNz8x6TfKbh9XQ</recordid><startdate>20140321</startdate><enddate>20140321</enddate><creator>Bertrand, Benoît</creator><creator>Casini, Angela</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140321</creationdate><title>A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds</title><author>Bertrand, Benoît ; Casini, Angela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-ecccb9896b2fb5798d6e74fd0d761fa7b5824164645c21b638e165ec06cb1bea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alkynes - chemistry</topic><topic>Alkynes - pharmacology</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Humans</topic><topic>Methane - analogs & derivatives</topic><topic>Methane - chemistry</topic><topic>Methane - pharmacology</topic><topic>Neoplasms - drug therapy</topic><topic>Organogold Compounds - chemistry</topic><topic>Organogold Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bertrand, Benoît</creatorcontrib><creatorcontrib>Casini, Angela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertrand, Benoît</au><au>Casini, Angela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><addtitle>Dalton Trans</addtitle><date>2014-03-21</date><risdate>2014</risdate><volume>43</volume><issue>11</issue><spage>429</spage><epage>4219</epage><pages>429-4219</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an important place in the field of medicinal inorganic chemistry due to their unique chemical properties with respect to gold coordination compounds. In fact, several studies have proved that they can be used to develop highly efficient metal-based drugs with possible applications in the treatment of cancer. This Perspective summarizes the results obtained for different families of bioactive organometallic gold compounds including cyclometallated gold(
iii
) complexes with C,N-donor ligands, gold(
i
) and gold(
i
/
iii
) N-heterocyclic (NHC) carbene complexes, as well as gold(
i
) alkynyl complexes, with promising anticancer effects. Most importantly, we will focus on recent developments in the field and discuss the potential of this class of organometallic compounds in relation to their versatile chemistry and innovative mechanisms of action.
This review provides an overview of the recent results concerning anticancer organometallic gold compounds and related mechanistic insights.</abstract><cop>England</cop><pmid>24225667</pmid><doi>10.1039/c3dt52524d</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2014-03, Vol.43 (11), p.429-4219 |
| issn | 1477-9226 1477-9234 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alkynes - chemistry Alkynes - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Humans Methane - analogs & derivatives Methane - chemistry Methane - pharmacology Neoplasms - drug therapy Organogold Compounds - chemistry Organogold Compounds - pharmacology |
| title | A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds |
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