Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery
The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand...
Gespeichert in:
| Veröffentlicht in: | Chemical Society reviews 2014-01, Vol.43 (1), p.444-472 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 472 |
|---|---|
| container_issue | 1 |
| container_start_page | 444 |
| container_title | Chemical Society reviews |
| container_volume | 43 |
| creator | Raemdonck, Koen Braeckmans, Kevin Demeester, Jo De Smedt, Stefaan C |
| description | The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.
This review article presents an updated overview of hybrid lipid-polymer matrix nanocomposites with a core-shell nanoarchitecture, focusing on various nanoengineering approaches and drug delivery applications. |
| doi_str_mv | 10.1039/c3cs60299k |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_C3CS60299K</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1768572007</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-3ede24d519417807067efb4f82991927f9622d7feae9b5bad71ffe681f281aef3</originalsourceid><addsrcrecordid>eNqNkT1PwzAQQC0EoqWwsIM8IqSA7bh2zIYqvkQRA7ASJfG5NSRxsNNC_z2BljLCdCfd05NOD6F9Sk4oidVpERdBEKbU6wbqUy5IxCXnm6hPYiIiQijroZ0QXrqNSsG2UY9xSsgwoX30fAd-YusJbqeAcwgtdgbnrp3id-dLHc7wdJF7q3FpG6sjqOdQugY0rrLW2w9cZ7UrXNW4YFsI2NZY-9kEayjtHPxiF22ZrAywt5oD9HR58Ti6jsb3Vzej83FUcCnbKAYNjOshVZzKhEgiJJicm6R7iiomjRKMaWkgA5UP80xLagyIhBqW0AxMPEBHS2_j3duseyOtbCigLLMa3CyknbUzcBGzf6AiGUpGiPwb5YIninOiOvR4iRbeheDBpI23VeYXKSXpV6V0FI8evivddvDhyjvLK9Br9CdLBxwsAR-K9fU3c_wJEfuWzQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1464894409</pqid></control><display><type>article</type><title>Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals</source><source>Alma/SFX Local Collection</source><creator>Raemdonck, Koen ; Braeckmans, Kevin ; Demeester, Jo ; De Smedt, Stefaan C</creator><creatorcontrib>Raemdonck, Koen ; Braeckmans, Kevin ; Demeester, Jo ; De Smedt, Stefaan C</creatorcontrib><description>The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.
This review article presents an updated overview of hybrid lipid-polymer matrix nanocomposites with a core-shell nanoarchitecture, focusing on various nanoengineering approaches and drug delivery applications.</description><identifier>ISSN: 0306-0012</identifier><identifier>EISSN: 1460-4744</identifier><identifier>DOI: 10.1039/c3cs60299k</identifier><identifier>PMID: 24100581</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Biomimetics ; Drug delivery systems ; Drug Delivery Systems - methods ; Effectiveness ; Humans ; Hydrogel, Polyethylene Glycol Dimethacrylate ; Lipids ; Lipids - chemistry ; Merging ; Nanocomposites ; Nanocomposites - administration & dosage ; Nanocomposites - chemistry ; Nanocomposites - toxicity ; Nanoengineering ; Nanostructure ; Nanotechnology ; Polyesters - chemistry ; Silicon Dioxide</subject><ispartof>Chemical Society reviews, 2014-01, Vol.43 (1), p.444-472</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-3ede24d519417807067efb4f82991927f9622d7feae9b5bad71ffe681f281aef3</citedby><cites>FETCH-LOGICAL-c477t-3ede24d519417807067efb4f82991927f9622d7feae9b5bad71ffe681f281aef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24100581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raemdonck, Koen</creatorcontrib><creatorcontrib>Braeckmans, Kevin</creatorcontrib><creatorcontrib>Demeester, Jo</creatorcontrib><creatorcontrib>De Smedt, Stefaan C</creatorcontrib><title>Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery</title><title>Chemical Society reviews</title><addtitle>Chem Soc Rev</addtitle><description>The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.
This review article presents an updated overview of hybrid lipid-polymer matrix nanocomposites with a core-shell nanoarchitecture, focusing on various nanoengineering approaches and drug delivery applications.</description><subject>Animals</subject><subject>Biomimetics</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Effectiveness</subject><subject>Humans</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate</subject><subject>Lipids</subject><subject>Lipids - chemistry</subject><subject>Merging</subject><subject>Nanocomposites</subject><subject>Nanocomposites - administration & dosage</subject><subject>Nanocomposites - chemistry</subject><subject>Nanocomposites - toxicity</subject><subject>Nanoengineering</subject><subject>Nanostructure</subject><subject>Nanotechnology</subject><subject>Polyesters - chemistry</subject><subject>Silicon Dioxide</subject><issn>0306-0012</issn><issn>1460-4744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1PwzAQQC0EoqWwsIM8IqSA7bh2zIYqvkQRA7ASJfG5NSRxsNNC_z2BljLCdCfd05NOD6F9Sk4oidVpERdBEKbU6wbqUy5IxCXnm6hPYiIiQijroZ0QXrqNSsG2UY9xSsgwoX30fAd-YusJbqeAcwgtdgbnrp3id-dLHc7wdJF7q3FpG6sjqOdQugY0rrLW2w9cZ7UrXNW4YFsI2NZY-9kEayjtHPxiF22ZrAywt5oD9HR58Ti6jsb3Vzej83FUcCnbKAYNjOshVZzKhEgiJJicm6R7iiomjRKMaWkgA5UP80xLagyIhBqW0AxMPEBHS2_j3duseyOtbCigLLMa3CyknbUzcBGzf6AiGUpGiPwb5YIninOiOvR4iRbeheDBpI23VeYXKSXpV6V0FI8evivddvDhyjvLK9Br9CdLBxwsAR-K9fU3c_wJEfuWzQ</recordid><startdate>20140107</startdate><enddate>20140107</enddate><creator>Raemdonck, Koen</creator><creator>Braeckmans, Kevin</creator><creator>Demeester, Jo</creator><creator>De Smedt, Stefaan C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140107</creationdate><title>Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery</title><author>Raemdonck, Koen ; Braeckmans, Kevin ; Demeester, Jo ; De Smedt, Stefaan C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-3ede24d519417807067efb4f82991927f9622d7feae9b5bad71ffe681f281aef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biomimetics</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - methods</topic><topic>Effectiveness</topic><topic>Humans</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate</topic><topic>Lipids</topic><topic>Lipids - chemistry</topic><topic>Merging</topic><topic>Nanocomposites</topic><topic>Nanocomposites - administration & dosage</topic><topic>Nanocomposites - chemistry</topic><topic>Nanocomposites - toxicity</topic><topic>Nanoengineering</topic><topic>Nanostructure</topic><topic>Nanotechnology</topic><topic>Polyesters - chemistry</topic><topic>Silicon Dioxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raemdonck, Koen</creatorcontrib><creatorcontrib>Braeckmans, Kevin</creatorcontrib><creatorcontrib>Demeester, Jo</creatorcontrib><creatorcontrib>De Smedt, Stefaan C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical Society reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raemdonck, Koen</au><au>Braeckmans, Kevin</au><au>Demeester, Jo</au><au>De Smedt, Stefaan C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery</atitle><jtitle>Chemical Society reviews</jtitle><addtitle>Chem Soc Rev</addtitle><date>2014-01-07</date><risdate>2014</risdate><volume>43</volume><issue>1</issue><spage>444</spage><epage>472</epage><pages>444-472</pages><issn>0306-0012</issn><eissn>1460-4744</eissn><abstract>The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.
This review article presents an updated overview of hybrid lipid-polymer matrix nanocomposites with a core-shell nanoarchitecture, focusing on various nanoengineering approaches and drug delivery applications.</abstract><cop>England</cop><pmid>24100581</pmid><doi>10.1039/c3cs60299k</doi><tpages>29</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-0012 |
| ispartof | Chemical Society reviews, 2014-01, Vol.43 (1), p.444-472 |
| issn | 0306-0012 1460-4744 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_C3CS60299K |
| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Animals Biomimetics Drug delivery systems Drug Delivery Systems - methods Effectiveness Humans Hydrogel, Polyethylene Glycol Dimethacrylate Lipids Lipids - chemistry Merging Nanocomposites Nanocomposites - administration & dosage Nanocomposites - chemistry Nanocomposites - toxicity Nanoengineering Nanostructure Nanotechnology Polyesters - chemistry Silicon Dioxide |
| title | Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T03%3A58%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Merging%20the%20best%20of%20both%20worlds:%20hybrid%20lipid-enveloped%20matrix%20nanocomposites%20in%20drug%20delivery&rft.jtitle=Chemical%20Society%20reviews&rft.au=Raemdonck,%20Koen&rft.date=2014-01-07&rft.volume=43&rft.issue=1&rft.spage=444&rft.epage=472&rft.pages=444-472&rft.issn=0306-0012&rft.eissn=1460-4744&rft_id=info:doi/10.1039/c3cs60299k&rft_dat=%3Cproquest_cross%3E1768572007%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1464894409&rft_id=info:pmid/24100581&rfr_iscdi=true |