Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction...

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Veröffentlicht in:MedChemComm 2013, Vol.4 (1), p.120-124
Hauptverfasser: Herzog, Ido M., Feldman, Mark, Eldar-Boock, Anat, Satchi-Fainaro, Ronit, Fridman, Micha
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creator Herzog, Ido M.
Feldman, Mark
Eldar-Boock, Anat
Satchi-Fainaro, Ronit
Fridman, Micha
description Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction in red blood cells hemolysis, demonstrating that it is possible to maintain the antimicrobial potency of these molecules while reducing their undesired hemolytic effect through chemical modifications.
doi_str_mv 10.1039/C2MD20162C
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title Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity
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