Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium

Previous work indicated that E-selectin mediates transient interactions between leukocytes and cytokine-activated endothelium in vitro. Here we examine the role of E-selectin in blood leukocyte interactions with microvascular endothelium in vivo. E-selectin-deficient (E-/-) mice were produced by gen...

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Veröffentlicht in:	Microcirculation (New York, N.Y. 1994) N.Y. 1994), 1998, Vol.5 (2-3), p.153-171
Hauptverfasser:	Milstone, D S, Fukumura, D, Padgett, R C, O'Donnell, P E, Davis, V M, Benavidez, O J, Monsky, W L, Melder, R J, Jain, R K, Gimbrone, Jr, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - physiology Cell Movement - physiology Cytokines - physiology E-Selectin - genetics E-Selectin - physiology Endothelium, Vascular - physiology Female Gene Expression Leukocytes - physiology Lipopolysaccharides - toxicity Male Mice Mice, Knockout Microcirculation - physiology Skin - blood supply Tumor Necrosis Factor-alpha - pharmacology
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