Effects of tumor necrosis factor alpha on leptin secretion and gene expression : relationship to changes of glucose metabolism in isolated rat adipocytes

Our objective was to determine the effects of prolonged exposure to tumor necrosis factor-alpha (TNF-alpha) on leptin secretion from and leptin (OB) gene expression in isolated adipocytes. Because glucose uptake and the metabolism of glucose beyond lactate are important determinants of leptin produc...

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Veröffentlicht in:	International Journal of Obesity 1999-08, Vol.23 (8), p.896-903
Hauptverfasser:	MEDINA, E. A, STANHOPE, K. L, MIZUNO, T. M, MOBBS, C. V, GREGOIRE, F, HUBBARD, N. E, ERICKSON, K. L, HAVEL, P. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Animals Biological and medical sciences Blotting, Northern Cells, Cultured Fundamental and applied biological sciences. Psychology Gene Expression General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Glucose - metabolism Insulin - metabolism Lactic Acid - metabolism Leptin Male Proteins - genetics Proteins - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - analysis Time Factors Tumor Necrosis Factor-alpha - metabolism Vertebrates: endocrinology
Online-Zugang:	Volltext
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