Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (bp)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone
We investigated the effect of obesity on the serum levels of total and free IGF-1 and their relationship to the circulating levels of insulin and IGF binding proteins (IGFBPs) in age and sex-matched groups. The study included 43 obese subjects (ideal body weight; IBW > 120%) and 45 controls (IBW...
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| Veröffentlicht in: | International Journal of Obesity 1997-05, Vol.21 (5), p.355-359 |
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| container_title | International Journal of Obesity |
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| creator | NAM, S. Y LEE, E. J KIM, K. R CHA, B. S SONG, Y. D LIM, S. K LEE, H. C HUH, K. B |
| description | We investigated the effect of obesity on the serum levels of total and free IGF-1 and their relationship to the circulating levels of insulin and IGF binding proteins (IGFBPs) in age and sex-matched groups.
The study included 43 obese subjects (ideal body weight; IBW > 120%) and 45 controls (IBW < 100%). All of the subjects were male.
Total IGF-1, free IGF-1, IGFBP-1, IGFBP-2, IGFBP-3, and insulin were measured in obese subjects and normal control subjects.
No significant differences in the circulating levels of total and IGFBP-3 were observed between the obese and control groups. In contrast to total IGF-1, free IGF-1 in obese subjects was significantly increased compared to normal controls (P < 0.05). Serum total and free IGF-1 were inversely correlated with age (r = -0.42, P = 0.001, and -0.44, P = 0.001). Fasting serum insulin concentrations were elevated in all the obese subjects (P < 0.05) and positively correlated with IBW (r = 0.57, P = 0.001). The levels of serum GH and IGFBP-1 were suppressed in all the obese subjects (P < 0.05). IGFBP-1 was inversely correlated with IBW (r = -0.51, P = 0.001) and serum insulin concentrations (r = -0.48, P = 0.001). The IGFBP-2 concentrations were also suppressed in obese subjects and inversely related to free IGF-1 (r = -0.48, P = 0.001). Using multiple linear regression analysis, total IGF-1 and insulin concentrations were positively correlated (r = 0.58, P = 0.001) and free IGF-1 and IGFBP-1 concentrations were negatively correlated (r = -0.57, P = 0.001).
We confirmed that total IGF-1 and IGFBP-3 concentrations were not significantly different between the obese and control groups, despite GH hyposecretion in obesity. We also found that free IGF-1 concentrations were higher in obese subjects than in normal controls. It seems likely that overnutrition and chronic hyperinsulinaemia in obesity may alter this regulated growth response by insulin stimulation of IGF-1 production and suppression of hepatic IGFBP-1 and IGFBP-2 production, which may inhibit IGF-1 bioactivity. |
| doi_str_mv | 10.1038/sj.ijo.0800412 |
| format | Article |
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The study included 43 obese subjects (ideal body weight; IBW > 120%) and 45 controls (IBW < 100%). All of the subjects were male.
Total IGF-1, free IGF-1, IGFBP-1, IGFBP-2, IGFBP-3, and insulin were measured in obese subjects and normal control subjects.
No significant differences in the circulating levels of total and IGFBP-3 were observed between the obese and control groups. In contrast to total IGF-1, free IGF-1 in obese subjects was significantly increased compared to normal controls (P < 0.05). Serum total and free IGF-1 were inversely correlated with age (r = -0.42, P = 0.001, and -0.44, P = 0.001). Fasting serum insulin concentrations were elevated in all the obese subjects (P < 0.05) and positively correlated with IBW (r = 0.57, P = 0.001). The levels of serum GH and IGFBP-1 were suppressed in all the obese subjects (P < 0.05). IGFBP-1 was inversely correlated with IBW (r = -0.51, P = 0.001) and serum insulin concentrations (r = -0.48, P = 0.001). The IGFBP-2 concentrations were also suppressed in obese subjects and inversely related to free IGF-1 (r = -0.48, P = 0.001). Using multiple linear regression analysis, total IGF-1 and insulin concentrations were positively correlated (r = 0.58, P = 0.001) and free IGF-1 and IGFBP-1 concentrations were negatively correlated (r = -0.57, P = 0.001).
We confirmed that total IGF-1 and IGFBP-3 concentrations were not significantly different between the obese and control groups, despite GH hyposecretion in obesity. We also found that free IGF-1 concentrations were higher in obese subjects than in normal controls. It seems likely that overnutrition and chronic hyperinsulinaemia in obesity may alter this regulated growth response by insulin stimulation of IGF-1 production and suppression of hepatic IGFBP-1 and IGFBP-2 production, which may inhibit IGF-1 bioactivity.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0800412</identifier><identifier>PMID: 9152736</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - analysis ; Cholesterol - blood ; Cohort Studies ; Human Growth Hormone - blood ; Humans ; Insulin - blood ; Insulin-Like Growth Factor Binding Protein 1 - blood ; Insulin-Like Growth Factor Binding Protein 2 - blood ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor Binding Proteins - blood ; Insulin-Like Growth Factor I - analysis ; Korea ; Linear Models ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Obesity ; Obesity - blood ; Reference Values ; Triglycerides - blood</subject><ispartof>International Journal of Obesity, 1997-05, Vol.21 (5), p.355-359</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c288t-577d13749c32d1a4aaf875e4f57519162d819823f3a895e23f1fe57b7439da533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2657202$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9152736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAM, S. Y</creatorcontrib><creatorcontrib>LEE, E. J</creatorcontrib><creatorcontrib>KIM, K. R</creatorcontrib><creatorcontrib>CHA, B. S</creatorcontrib><creatorcontrib>SONG, Y. D</creatorcontrib><creatorcontrib>LIM, S. K</creatorcontrib><creatorcontrib>LEE, H. C</creatorcontrib><creatorcontrib>HUH, K. B</creatorcontrib><title>Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (bp)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone</title><title>International Journal of Obesity</title><addtitle>Int J Obes Relat Metab Disord</addtitle><description>We investigated the effect of obesity on the serum levels of total and free IGF-1 and their relationship to the circulating levels of insulin and IGF binding proteins (IGFBPs) in age and sex-matched groups.
The study included 43 obese subjects (ideal body weight; IBW > 120%) and 45 controls (IBW < 100%). All of the subjects were male.
Total IGF-1, free IGF-1, IGFBP-1, IGFBP-2, IGFBP-3, and insulin were measured in obese subjects and normal control subjects.
No significant differences in the circulating levels of total and IGFBP-3 were observed between the obese and control groups. In contrast to total IGF-1, free IGF-1 in obese subjects was significantly increased compared to normal controls (P < 0.05). Serum total and free IGF-1 were inversely correlated with age (r = -0.42, P = 0.001, and -0.44, P = 0.001). Fasting serum insulin concentrations were elevated in all the obese subjects (P < 0.05) and positively correlated with IBW (r = 0.57, P = 0.001). The levels of serum GH and IGFBP-1 were suppressed in all the obese subjects (P < 0.05). IGFBP-1 was inversely correlated with IBW (r = -0.51, P = 0.001) and serum insulin concentrations (r = -0.48, P = 0.001). The IGFBP-2 concentrations were also suppressed in obese subjects and inversely related to free IGF-1 (r = -0.48, P = 0.001). Using multiple linear regression analysis, total IGF-1 and insulin concentrations were positively correlated (r = 0.58, P = 0.001) and free IGF-1 and IGFBP-1 concentrations were negatively correlated (r = -0.57, P = 0.001).
We confirmed that total IGF-1 and IGFBP-3 concentrations were not significantly different between the obese and control groups, despite GH hyposecretion in obesity. We also found that free IGF-1 concentrations were higher in obese subjects than in normal controls. 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Y</creatorcontrib><creatorcontrib>LEE, E. J</creatorcontrib><creatorcontrib>KIM, K. R</creatorcontrib><creatorcontrib>CHA, B. S</creatorcontrib><creatorcontrib>SONG, Y. D</creatorcontrib><creatorcontrib>LIM, S. K</creatorcontrib><creatorcontrib>LEE, H. C</creatorcontrib><creatorcontrib>HUH, K. B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAM, S. Y</au><au>LEE, E. J</au><au>KIM, K. R</au><au>CHA, B. S</au><au>SONG, Y. D</au><au>LIM, S. K</au><au>LEE, H. C</au><au>HUH, K. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (bp)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone</atitle><jtitle>International Journal of Obesity</jtitle><addtitle>Int J Obes Relat Metab Disord</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>21</volume><issue>5</issue><spage>355</spage><epage>359</epage><pages>355-359</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>We investigated the effect of obesity on the serum levels of total and free IGF-1 and their relationship to the circulating levels of insulin and IGF binding proteins (IGFBPs) in age and sex-matched groups.
The study included 43 obese subjects (ideal body weight; IBW > 120%) and 45 controls (IBW < 100%). All of the subjects were male.
Total IGF-1, free IGF-1, IGFBP-1, IGFBP-2, IGFBP-3, and insulin were measured in obese subjects and normal control subjects.
No significant differences in the circulating levels of total and IGFBP-3 were observed between the obese and control groups. In contrast to total IGF-1, free IGF-1 in obese subjects was significantly increased compared to normal controls (P < 0.05). Serum total and free IGF-1 were inversely correlated with age (r = -0.42, P = 0.001, and -0.44, P = 0.001). Fasting serum insulin concentrations were elevated in all the obese subjects (P < 0.05) and positively correlated with IBW (r = 0.57, P = 0.001). The levels of serum GH and IGFBP-1 were suppressed in all the obese subjects (P < 0.05). IGFBP-1 was inversely correlated with IBW (r = -0.51, P = 0.001) and serum insulin concentrations (r = -0.48, P = 0.001). The IGFBP-2 concentrations were also suppressed in obese subjects and inversely related to free IGF-1 (r = -0.48, P = 0.001). Using multiple linear regression analysis, total IGF-1 and insulin concentrations were positively correlated (r = 0.58, P = 0.001) and free IGF-1 and IGFBP-1 concentrations were negatively correlated (r = -0.57, P = 0.001).
We confirmed that total IGF-1 and IGFBP-3 concentrations were not significantly different between the obese and control groups, despite GH hyposecretion in obesity. We also found that free IGF-1 concentrations were higher in obese subjects than in normal controls. It seems likely that overnutrition and chronic hyperinsulinaemia in obesity may alter this regulated growth response by insulin stimulation of IGF-1 production and suppression of hepatic IGFBP-1 and IGFBP-2 production, which may inhibit IGF-1 bioactivity.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>9152736</pmid><doi>10.1038/sj.ijo.0800412</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 1997-05, Vol.21 (5), p.355-359 |
| issn | 0307-0565 1476-5497 |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Blood Glucose - analysis Cholesterol - blood Cohort Studies Human Growth Hormone - blood Humans Insulin - blood Insulin-Like Growth Factor Binding Protein 1 - blood Insulin-Like Growth Factor Binding Protein 2 - blood Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor Binding Proteins - blood Insulin-Like Growth Factor I - analysis Korea Linear Models Male Medical sciences Metabolic diseases Middle Aged Obesity Obesity - blood Reference Values Triglycerides - blood |
| title | Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (bp)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone |
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